Abstract
Caveolae, small invaginations of the plasma membrane, are a characteristic feature of many mammalian cells. The best-characterised caveolar protein is the integral membrane protein, VIP21-caveolin. We now describe a novel homologue of VIP21-caveolin, M-caveolin, which is expressed exclusively in muscle. M-caveolin was shown to be expressed in differentiated myotubes but not myoblasts. Epitope-tagged M-caveolin expressed in non-muscle cells was targetted to surface caveolae where it colocalized with endogenous VIP21-caveolin. M-caveolin may play a specialised role in the caveolae of muscle cells.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Carrier Proteins / chemistry
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Caveolin 1
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Caveolin 3
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Caveolins*
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Cell Differentiation / genetics
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Cloning, Molecular
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Conserved Sequence / genetics
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Fluorescent Antibody Technique
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Gene Expression / genetics
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HeLa Cells
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Humans
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Membrane Proteins / chemistry*
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Membrane Proteins / genetics
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Membrane Proteins / isolation & purification
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Mice
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Microscopy, Electron
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Molecular Sequence Data
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Muscle Proteins / chemistry*
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Muscle, Skeletal / chemistry*
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Rats
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Sequence Alignment
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Sequence Analysis
Substances
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CAV1 protein, human
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Carrier Proteins
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Cav1 protein, mouse
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Cav1 protein, rat
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Cav3 protein, mouse
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Cav3 protein, rat
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Caveolin 1
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Caveolin 3
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Caveolins
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Membrane Proteins
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Muscle Proteins