Abstract
A novel potassium channel beta-subunit (Kv beta 3) was cloned from rat brain being the third member of a Kv beta subunit gene family. It is a protein of 403 amino acid residues with a 68% amino acid sequence homology to Kv beta 1.1. Kv beta 3 is primarily expressed in rat brain having a distribution distinct to those of Kv beta 1.1 and Kv beta 2. This subunit also has a long N-terminal structure and induces inactivation in N-terminal deleted Kv1.4 but not in other members of the Kv1 channel family. Similarly to Kv beta 1.1, the Kv beta 3-induced inactivation is regulated by the intracellular redox potential.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain / anatomy & histology
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Brain Chemistry*
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DNA, Complementary / genetics
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Electric Conductivity
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Gene Library
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Large-Conductance Calcium-Activated Potassium Channel beta Subunits
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Molecular Sequence Data
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Multigene Family
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / isolation & purification*
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Nerve Tissue Proteins / metabolism
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Oocytes
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Patch-Clamp Techniques
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Potassium Channels / genetics
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Potassium Channels / isolation & purification*
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Potassium Channels / metabolism
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Protein Conformation
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RNA, Messenger / analysis
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Rats
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Tissue Distribution
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Xenopus
Substances
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DNA, Complementary
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Kcnab3 protein, rat
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Large-Conductance Calcium-Activated Potassium Channel beta Subunits
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Nerve Tissue Proteins
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Potassium Channels
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RNA, Messenger
Associated data
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GENBANK/X70662
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GENBANK/X76723