Abstract
In the present study, we demonstrate that the Ca(2+)-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca(2+)-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca(2+)-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / analogs & derivatives
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Adenosine / pharmacology
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Adenylyl Cyclase Inhibitors
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Adenylyl Cyclases / metabolism*
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Animals
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Caffeine / analogs & derivatives
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Caffeine / pharmacology
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Calcium / pharmacology
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Circadian Rhythm / physiology*
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Colforsin / pharmacology
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Corpus Striatum / enzymology*
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Cyclic AMP / metabolism
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Guanosine Diphosphate / pharmacology
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Isoenzymes / genetics
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Male
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Motor Activity / drug effects
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Phenethylamines / pharmacology
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Purinergic P1 Receptor Agonists
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Rats
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Rats, Sprague-Dawley
Substances
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Adenylyl Cyclase Inhibitors
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Isoenzymes
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Phenethylamines
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Purinergic P1 Receptor Agonists
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2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
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Guanosine Diphosphate
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8-(3-chlorostyryl)caffeine
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Colforsin
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Caffeine
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Cyclic AMP
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Adenylyl Cyclases
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Adenosine
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Calcium