Circadian rhythm in the Ca(2+)-inhibitable adenylyl activity of the rat striatum

FEBS Lett. 1996 May 6;385(3):205-8. doi: 10.1016/0014-5793(96)00370-5.

Abstract

In the present study, we demonstrate that the Ca(2+)-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca(2+)-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca(2+)-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / pharmacology
  • Adenylyl Cyclase Inhibitors
  • Adenylyl Cyclases / metabolism*
  • Animals
  • Caffeine / analogs & derivatives
  • Caffeine / pharmacology
  • Calcium / pharmacology
  • Circadian Rhythm / physiology*
  • Colforsin / pharmacology
  • Corpus Striatum / enzymology*
  • Cyclic AMP / metabolism
  • Guanosine Diphosphate / pharmacology
  • Isoenzymes / genetics
  • Male
  • Motor Activity / drug effects
  • Phenethylamines / pharmacology
  • Purinergic P1 Receptor Agonists
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Adenylyl Cyclase Inhibitors
  • Isoenzymes
  • Phenethylamines
  • Purinergic P1 Receptor Agonists
  • 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
  • Guanosine Diphosphate
  • 8-(3-chlorostyryl)caffeine
  • Colforsin
  • Caffeine
  • Cyclic AMP
  • Adenylyl Cyclases
  • Adenosine
  • Calcium