Abstract
A series of experiments were designed to examine the potential induction of apoptosis by nitric oxide (NO) donors on cortical neuronal cell culture. A 24 h exposure of three different NO donors, 3-morpholinosydnonimine, S-nitroso-N-acetyl-penicillamine, and S-nitrosoglutathione, induced apoptosis as indicated by following histological (cellular and nuclear morphology) and biochemical markers (DNA oligonucleosomal fragmentation and protection by protein synthesis inhibitor).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis / drug effects*
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Cells, Cultured
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Cerebral Cortex / cytology*
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Cerebral Cortex / drug effects
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DNA / biosynthesis
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Electrophoresis, Agar Gel
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Glutathione / analogs & derivatives
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Glutathione / pharmacology
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Molsidomine / analogs & derivatives
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Molsidomine / pharmacology
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Nerve Tissue Proteins / biosynthesis
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Neurons / drug effects*
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Nitric Oxide / pharmacology*
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Nitroso Compounds / pharmacology
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Penicillamine / analogs & derivatives
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Penicillamine / pharmacology
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Rats
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Rats, Wistar
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S-Nitroso-N-Acetylpenicillamine
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S-Nitrosoglutathione
Substances
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Nerve Tissue Proteins
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Nitroso Compounds
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Nitric Oxide
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S-Nitrosoglutathione
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linsidomine
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S-Nitroso-N-Acetylpenicillamine
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DNA
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Molsidomine
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Glutathione
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Penicillamine