Abstract
Immunotoxins have been used to study the targeting of biologically active substances at neurons in vivo and to make experimental neural lesions. OX7-saporin, directed against Thy 1, destroys any neuron. 192 IgG-saporin, directed against the 'low affinity' neurotrophin receptor (p 75NTR), selectively destroys neurons expressing this receptor (sympathetic, sensory, cholinergic basal forebrain, cerebellar Purkinje). Anti-D beta H-saporin, directed against dopamine beta-hydroxylase, the enzyme that converts dopamine to norepinephrine, selectively destroys noradrenergic neurons (sympathetic, CNS). These agents show that several types of neural antigens may prove useful in treating pain, and anti-D beta H-saporin may be active against pheochromocytoma or neuroblastoma.
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology
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Cholinergic Agents / pharmacology
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Dopamine beta-Hydroxylase / immunology
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Forecasting
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Glycoside Hydrolases / pharmacology
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Humans
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Immunoconjugates
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Immunotoxins / pharmacology*
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Mice
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N-Glycosyl Hydrolases*
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Neurons / drug effects*
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Plant Proteins / pharmacology
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Rats
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Receptors, Interleukin-2 / genetics
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Receptors, Interleukin-2 / immunology
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Ribosome Inactivating Proteins, Type 1
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Saporins
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T-Lymphocytes
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Vasopressins / immunology
Substances
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192 IgG-saporin
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Antibodies, Monoclonal
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Cholinergic Agents
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Immunoconjugates
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Immunotoxins
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OX7-saporin
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Plant Proteins
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Receptors, Interleukin-2
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Ribosome Inactivating Proteins, Type 1
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anti-dopamine beta-hydroxylase immunotoxin
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Vasopressins
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Dopamine beta-Hydroxylase
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Glycoside Hydrolases
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N-Glycosyl Hydrolases
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Saporins