Cloning and characterization of multiple opioid receptors

H Akil; F Meng; A Mansour; R Thompson; G X Xie; S Watson

Cloning and characterization of multiple opioid receptors

NIDA Res Monogr. 1996:161:127-40.

Authors

H Akil¹, F Meng, A Mansour, R Thompson, G X Xie, S Watson

Affiliation

¹ Mental Health Research Institute, University of Michigan, Ann Arbor 48109-0720, USA.

PMID: 8784848

Abstract

Over the course of 1 to 2 years, the field has moved swiftly to investigate the functional and structural properties of the newly cloned opioid receptors. Achieving a better understanding of these macromolecules is likely to have profound implications for drug design aimed at the production of better analgesic drugs, for a more fundamental understanding of mechanisms of action of drugs of abuse, and for a more comprehensive knowledge base regarding the biology of opioid peptides in particular, and neuroactive peptides in general.

Publication types

Review

MeSH terms

Animals
Cloning, Molecular
Humans
Ligands
Peptides / metabolism
Receptors, Opioid, delta / chemistry
Receptors, Opioid, delta / genetics*
Receptors, Opioid, delta / metabolism
Receptors, Opioid, kappa / chemistry
Receptors, Opioid, kappa / genetics*
Receptors, Opioid, kappa / metabolism
Receptors, Opioid, mu / chemistry
Receptors, Opioid, mu / genetics*
Receptors, Opioid, mu / metabolism
Recombinant Fusion Proteins / chemistry
Recombinant Fusion Proteins / physiology
Structure-Activity Relationship

Substances

Ligands
Peptides
Receptors, Opioid, delta
Receptors, Opioid, kappa
Receptors, Opioid, mu
Recombinant Fusion Proteins