Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy

N R Richardson; D C Roberts

doi:10.1016/0165-0270(95)00153-0

Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy

J Neurosci Methods. 1996 May;66(1):1-11. doi: 10.1016/0165-0270(95)00153-0.

Authors

N R Richardson¹, D C Roberts

Affiliation

¹ Institute of Neuroscience, Carleton University, Ottawa, Canada.

PMID: 8794935
DOI: 10.1016/0165-0270(95)00153-0

Abstract

Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats. Session parameters adopted for use in our laboratory and the considerations relevant to them are described. The strengths and weaknesses of the PR schedule are also discussed.

Publication types

Review

MeSH terms

Animals
Cocaine / pharmacology*
Evaluation Studies as Topic
Narcotics / pharmacology*
Psychomotor Performance / drug effects
Rats
Self Administration / methods*
Self Administration / statistics & numerical data

Substances

Narcotics
Cocaine