Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus

Z Little; L M Grover; T J Teyler

doi:10.1016/0304-3940(95)12141-p

Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus

Neurosci Lett. 1995 Dec 1;201(1):73-6. doi: 10.1016/0304-3940(95)12141-p.

Authors

Z Little¹, L M Grover, T J Teyler

Affiliation

¹ Neurobiology Department, Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA. jzl@riker.neoucom.edu

PMID: 8830317
DOI: 10.1016/0304-3940(95)12141-p

Abstract

The necessity of metabotropic glutamate receptors (mGluRs) in the induction of long-term potentiation (LTP) has recently been questioned. We examined the effect of (R,S)-alpha-methyl-4-caboxyphenylglycine (MCPG), a selective mGluR antagonist, on two independent forms of LTP. One form induced by a 25 Hz/1 s tetanus is solely N-methyl-D-aspartate (NMDA) receptor-dependent. The other form induced by four 200 Hz/0.5 s bursts in the presence of APV is NMDA receptor-independent. In both paradigms the presence of MCPG prevented the induction of LTP by afferent activation.

MeSH terms

Animals
Benzoates / pharmacology*
Calcium Channels / drug effects
Calcium Channels / metabolism
Calcium Channels / physiology
Electric Stimulation
Electrophysiology
Excitatory Amino Acid Antagonists / pharmacology*
Glycine / analogs & derivatives*
Glycine / pharmacology
Hippocampus / drug effects
Hippocampus / physiology*
In Vitro Techniques
Ion Channel Gating / drug effects
Long-Term Potentiation / drug effects*
Rats
Receptors, Metabotropic Glutamate / antagonists & inhibitors*

Substances

Benzoates
Calcium Channels
Excitatory Amino Acid Antagonists
Receptors, Metabotropic Glutamate
alpha-methyl-4-carboxyphenylglycine
Glycine