Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS

A Makoff; C Pilling; K Harrington; P Emson

doi:10.1016/0169-328x(96)00110-6

Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS

Brain Res Mol Brain Res. 1996 Aug;40(1):165-70. doi: 10.1016/0169-328x(96)00110-6.

Authors

A Makoff¹, C Pilling, K Harrington, P Emson

Affiliation

¹ Biology Division, Wellcome Foundation, Kent, UK.

PMID: 8840028
DOI: 10.1016/0169-328x(96)00110-6

Abstract

Human metabotropic glutamate receptor type 7 (mGluR7) cDNA clones were isolated from a medulla cDNA library. The sequence, which includes a polymorphism, has 92% DNA sequence identity with rat mGluR7 and the predicted protein sequence has 99% identity. In-situ hybridization studies on human brain sections showed that mGluR7 mRNA has a widespread distribution with highest levels in the hippocampal formation, cerebral cortex and cerebellum.

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Brain / metabolism*
Cloning, Molecular
Humans
In Situ Hybridization
Molecular Sequence Data
Neurons / metabolism*
Oligonucleotides, Antisense
Organ Specificity
Polymorphism, Genetic
Purkinje Cells / metabolism
Pyramidal Cells / metabolism
Rats
Receptors, Metabotropic Glutamate / biosynthesis*
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid

Substances

Oligonucleotides, Antisense
Receptors, Metabotropic Glutamate
metabotropic glutamate receptor 7

Associated data

GENBANK/AJ010317
GENBANK/X94552