Abstract
The effect of 2-chloroadenosine, stable adenosine analog, and deoxycoformycin, adenosine deaminase inhibitor on brain ATP level and Na-K ATPase activity in ischemia were studied. The brain ATP level was increased after we administered both 2-chloroadenosine and deoxycoformycin, but Na-K ATPase activity did not change after deoxycoformycin. The results suggest that 2-chloroadenosine treatment influenced both the ATP production and membrane permeability due to cerebral ischemia. Deoxycoformycin did not protect the membrane permeability, although it increased the ATP production.
MeSH terms
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2-Chloroadenosine / pharmacology*
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2-Chloroadenosine / therapeutic use
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Adenosine Deaminase / physiology
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Adenosine Deaminase Inhibitors
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Adenosine Triphosphate / metabolism*
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Animals
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Brain Damage, Chronic / etiology
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Brain Damage, Chronic / prevention & control
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Brain Ischemia / complications
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Brain Ischemia / drug therapy*
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Brain Ischemia / metabolism
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Cell Membrane Permeability / drug effects
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Drug Evaluation, Preclinical
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Enzyme Inhibitors / pharmacology
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Enzyme Inhibitors / therapeutic use
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Female
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Gerbillinae
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Male
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Nerve Tissue Proteins / antagonists & inhibitors
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Nerve Tissue Proteins / metabolism*
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Neuroprotective Agents / pharmacology*
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Neuroprotective Agents / therapeutic use
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Pentostatin / pharmacology*
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Pentostatin / therapeutic use
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Sodium-Potassium-Exchanging ATPase / metabolism*
Substances
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Adenosine Deaminase Inhibitors
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Enzyme Inhibitors
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Nerve Tissue Proteins
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Neuroprotective Agents
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2-Chloroadenosine
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Pentostatin
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Adenosine Triphosphate
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Adenosine Deaminase
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Sodium-Potassium-Exchanging ATPase