Abstract
The ferret retinogeniculate projection is organized into on/off sublaminae within each eye-specific layer. The role of afferent activity in the formation of these sublaminae was examined. We report that when the activity of retinal ganglion cells is blocked with tetrodotoxin during postnatal weeks three and four, on/off sublamination is disrupted, supporting a role for afferent activity in the formation of this pattern.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Afferent Pathways / drug effects
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Animals
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Brain Mapping / methods*
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Eye / cytology
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Eye / drug effects*
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Ferrets
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Geniculate Bodies / drug effects*
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Microinjections
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Retinal Ganglion Cells / drug effects*
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Tetrodotoxin / pharmacology*
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Visual Pathways / drug effects*
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Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Substances
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Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
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Tetrodotoxin