(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

A J Doherty; M J Palmer; J M Henley; G L Collingridge; D E Jane

doi:10.1016/s0028-3908(97)00001-4

(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

Neuropharmacology. 1997 Feb;36(2):265-7. doi: 10.1016/s0028-3908(97)00001-4.

Authors

A J Doherty¹, M J Palmer, J M Henley, G L Collingridge, D E Jane

Affiliation

¹ Department of Anatomy, School of Medical Sciences, University of Bristol, UK.

PMID: 9144665
DOI: 10.1016/s0028-3908(97)00001-4

Abstract

A new phenylglycine derivative, (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), has been synthesized and shown to selectively activate mGlu5a receptors, compared to mGlu1 alpha receptors, when expressed in CHO cells. This selective mGlu5 receptor agonist also potentiates NMDA-induced depolarizations in rat hippocampal slices. CHPG may be a useful tool for studying the role of mGlu5 receptors in the central nervous system.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CHO Cells
Calcium / metabolism
Cricetinae
Excitatory Amino Acid Agonists / pharmacology*
Glycine / analogs & derivatives*
Glycine / pharmacology
Hippocampus / drug effects
Hippocampus / metabolism*
In Vitro Techniques
N-Methylaspartate / pharmacology*
Phenylacetates / pharmacology*
Rats
Receptors, Metabotropic Glutamate / drug effects*

Substances

2-chloro-5-hydroxyphenylglycine
Excitatory Amino Acid Agonists
Phenylacetates
Receptors, Metabotropic Glutamate
N-Methylaspartate
Calcium
Glycine