Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices

Neuropharmacology. 1997 Mar;36(3):401-3. doi: 10.1016/s0028-3908(97)00014-2.

Abstract

The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzoates / pharmacology*
  • Cerebellum / drug effects*
  • Dose-Response Relationship, Drug
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Glycine / analogs & derivatives*
  • Glycine / pharmacology
  • Rats
  • Receptors, Metabotropic Glutamate / drug effects*
  • Synaptic Transmission / drug effects*

Substances

  • Benzoates
  • Excitatory Amino Acid Antagonists
  • Receptors, Metabotropic Glutamate
  • 4-carboxyphenylglycine
  • Glycine