Abstract
The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzoates / pharmacology*
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Cerebellum / drug effects*
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Dose-Response Relationship, Drug
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Excitatory Amino Acid Antagonists / pharmacology*
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Glycine / analogs & derivatives*
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Glycine / pharmacology
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Rats
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Receptors, Metabotropic Glutamate / drug effects*
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Synaptic Transmission / drug effects*
Substances
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Benzoates
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Excitatory Amino Acid Antagonists
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Receptors, Metabotropic Glutamate
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4-carboxyphenylglycine
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Glycine