Abstract
Bcl-2 is an oncogenic protein that acts by inhibiting programmed cell death. The mechanisms used by this and related anti-apoptotic proteins to protect cells from cytotoxic stimuli are now emerging, with the discovery that Bcl-2 can function both as an ion channel and as an adaptor or docking protein.
MeSH terms
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Animals
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Apoptosis*
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Caenorhabditis elegans Proteins*
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Calcium-Binding Proteins / metabolism*
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Cytosol / metabolism
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Dimerization
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Helminth Proteins / metabolism*
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Humans
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Intracellular Membranes / metabolism
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Ion Channels / chemistry
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Ion Channels / physiology*
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Protein Binding
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Protein Conformation
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Protein Structure, Secondary
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Proto-Oncogene Proteins / chemistry
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins / physiology*
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Proto-Oncogene Proteins c-bcl-2 / chemistry
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Proto-Oncogene Proteins c-bcl-2 / physiology*
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bcl-X Protein
Substances
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BCL2L1 protein, human
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Caenorhabditis elegans Proteins
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Calcium-Binding Proteins
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Ced-4 protein, C elegans
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Helminth Proteins
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Ion Channels
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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bcl-X Protein