Abstract
We have isolated a novel cDNA, vesl, that was induced during convulsive seizure in the rat hippocampus. The vesl gene encodes a protein of 186 amino acids that has significant homology to the EVH1 domain of the VASP/Ena family of proteins implicated in the control of microfilament dynamics. The expression of vesl mRNA was induced in the granule cell layer during persistent long-term potentiation (LTP) of the dentate gyrus in an NMDA receptor-dependent manner. Furthermore, vesl mRNA was expressed at a high level during hippocampal synaptogenesis. We suggest that the Vesl protein may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Northern
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Carrier Proteins / genetics*
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Cell Adhesion Molecules / genetics*
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Gene Expression
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Gene Expression Regulation*
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Hippocampus / drug effects
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Hippocampus / growth & development
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Hippocampus / metabolism
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Homer Scaffolding Proteins
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Kainic Acid / pharmacology
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Long-Term Potentiation*
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Male
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Microfilament Proteins
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Molecular Sequence Data
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Neuropeptides / genetics*
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Phosphoproteins / genetics*
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RNA, Messenger / analysis
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RNA, Messenger / metabolism
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Rats
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Rats, Wistar
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Seizures / metabolism*
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Synapses / physiology*
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Tissue Distribution
Substances
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Carrier Proteins
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Cell Adhesion Molecules
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Homer Scaffolding Proteins
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Microfilament Proteins
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Neuropeptides
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Phosphoproteins
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RNA, Messenger
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vasodilator-stimulated phosphoprotein
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Kainic Acid