Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism

E Gould; P Tanapat; H A Cameron

doi:10.1016/s0165-3806(97)00079-5

Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism

Brain Res Dev Brain Res. 1997 Oct 20;103(1):91-3. doi: 10.1016/s0165-3806(97)00079-5.

Authors

E Gould¹, P Tanapat, H A Cameron

Affiliation

¹ Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA. goulde@princeton.edu

PMID: 9370064
DOI: 10.1016/s0165-3806(97)00079-5

Abstract

Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyrus in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.

MeSH terms

Animals
Animals, Newborn
Cell Death / drug effects*
Cell Survival / drug effects
Corticosterone / pharmacology*
Dentate Gyrus / cytology*
Dentate Gyrus / drug effects
Dentate Gyrus / growth & development
Dizocilpine Maleate / pharmacology*
Female
Male
Neurons / cytology*
Neurons / drug effects
Neurons / physiology
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate / physiology*
Reference Values

Substances

Receptors, N-Methyl-D-Aspartate
Dizocilpine Maleate
Corticosterone