Abstract
We reported previously that the neuropeptide Y (NPY) Y1 receptor antagonist, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide (BIBP3226) has an anxiogenic-like effect in the elevated plus maze test in rats. In this study we investigated the effect of the corticotropin-releasing factor (CRF) receptor antagonist, alpha-helical-CRF(9-41) (alpha-h-CRF) on this response. BIBP3226 (5 microg, i.c.v.) induced an anxiogenic-like effect, which was blocked by pretreatment with alpha-h-CRF at a concentration (1 microg, i.c.v.) which alone failed to affect the elevated plus maze performance. Thus, the anxiogenic effect of a selective Y1 receptor blocker was prevented by the blockade of CRF receptors, suggesting antagonistic effects of endogenous NPY and CRF in shaping the response to novelty.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Anxiety Agents / administration & dosage
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Anti-Anxiety Agents / pharmacology*
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Anxiety*
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Arginine / administration & dosage
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Arginine / analogs & derivatives*
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Arginine / pharmacology
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Cerebral Ventricles / drug effects
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Cerebral Ventricles / physiology*
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Corticotropin-Releasing Hormone / administration & dosage
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Corticotropin-Releasing Hormone / pharmacology*
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Exploratory Behavior / drug effects
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Exploratory Behavior / physiology
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Hormone Antagonists / pharmacology*
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Injections, Intraventricular
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Male
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Maze Learning / drug effects
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Maze Learning / physiology*
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Peptide Fragments / administration & dosage
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Peptide Fragments / pharmacology*
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Rats
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Rats, Wistar
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Receptors, Neuropeptide Y / antagonists & inhibitors*
Substances
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Anti-Anxiety Agents
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BIBP 3226
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Hormone Antagonists
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Peptide Fragments
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Receptors, Neuropeptide Y
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neuropeptide Y-Y1 receptor
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Corticotropin-Releasing Hormone
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Arginine
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corticotropin releasing hormone (9-41)