Alzheimer's disease. A technical KO of amyloid-beta peptide

Nature. 1998 Jan 22;391(6665):339-40. doi: 10.1038/34800.
No abstract available

Publication types

  • Comment
  • News

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / genetics
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Aspartic Acid Endopeptidases
  • Biological Transport
  • CCAAT-Enhancer-Binding Proteins*
  • Cell Membrane / metabolism
  • DNA-Binding Proteins / metabolism
  • Endopeptidases / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins / drug effects
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Mice
  • Mutation
  • Nuclear Proteins / metabolism
  • Presenilin-1
  • Protein Processing, Post-Translational
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors*

Substances

  • Amyloid beta-Protein Precursor
  • CCAAT-Enhancer-Binding Proteins
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Nuclear Proteins
  • PSEN1 protein, human
  • Presenilin-1
  • SREBF1 protein, human
  • SREBP cleavage-activating protein
  • Srebf1 protein, mouse
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human
  • Bace1 protein, mouse