Abstract
A-currents (IA) of chick ciliary ganglion (CG) neurons were blocked reversibly by arachidonic acid and a non-metabolizable analog of arachidonic acid, 5,8,11,14-eicosatetraynoic acid. Inhibition of IA by both lipids was observed in whole-cell recordings and in excised inside-out patches, suggesting that Kv4 (Shal) subunits contribute to functional IA channels in CG neurons. Consistent with this, Kv4.2 and Kv4.3 cDNAs were isolated by RT-PCR from chick CG neurons.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arachidonic Acid / pharmacology*
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Chick Embryo
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Electric Conductivity
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Ganglia, Parasympathetic / cytology
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Ganglia, Parasympathetic / embryology
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Ganglia, Parasympathetic / physiology*
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Neurons / drug effects
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Neurons / metabolism
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Neurons / physiology*
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Potassium Channels / genetics*
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Potassium Channels, Voltage-Gated*
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RNA, Messenger / metabolism*
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Shal Potassium Channels
Substances
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Potassium Channels
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Potassium Channels, Voltage-Gated
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RNA, Messenger
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Shal Potassium Channels
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Arachidonic Acid