Immunocytochemical localization of mu-opioid receptor in primary afferent neurons containing substance P or calcitonin gene-related peptide. A light and electron microscope study in the rat

J L Li; Y Q Ding; Y Q Li; J S Li; S Nomura; T Kaneko; N Mizuno

doi:10.1016/s0006-8993(98)00332-1

Immunocytochemical localization of mu-opioid receptor in primary afferent neurons containing substance P or calcitonin gene-related peptide. A light and electron microscope study in the rat

Brain Res. 1998 Jun 1;794(2):347-52. doi: 10.1016/s0006-8993(98)00332-1.

Authors

J L Li¹, Y Q Ding, Y Q Li, J S Li, S Nomura, T Kaneko, N Mizuno

Affiliation

¹ Department of Anatomy and K.K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032, China.

PMID: 9622672
DOI: 10.1016/s0006-8993(98)00332-1

Abstract

Co-expression of mu-opioid receptor-like immunoreactivity (MOR-LI) with substance P (SP)- or calcitonin gene-related (CGRP)-LI was observed in rat trigeminal and dorsal root ganglion neurons. In particular, MOR-LI was found in axon terminals with SP- or CGRP-LI in laminae I and II of the medullary and spinal dorsal horns. MOR may be implicated in modulation of release of SP and CGRP from primary sensory afferents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcitonin Gene-Related Peptide / analysis*
Ganglia, Spinal / chemistry*
Ganglia, Spinal / cytology
Immunohistochemistry
Male
Microscopy / methods
Microscopy, Electron
Neurons, Afferent / chemistry*
Rats
Rats, Wistar
Receptors, Opioid, mu / analysis*
Substance P / analysis*
Trigeminal Ganglion / chemistry*
Trigeminal Ganglion / cytology

Substances

Receptors, Opioid, mu
Substance P
Calcitonin Gene-Related Peptide