Interleukin-10 reduces the endotoxin-induced hyperalgesia in mice

J Neuroimmunol. 1998 Jun 15;86(2):142-50. doi: 10.1016/s0165-5728(98)00027-7.

Abstract

In the endotoxin-induced inflammation, interleukin-10 reduced significantly, and in a dose-dependent manner, the inflammatory pain as assessed by mechanical and thermal tests. The levels of Tumour Necrosis Factor (TNF)alpha and NGF were upregulated at 1.5 h whereas those of IL-1beta at 6 h after ET injection. IL-10 downregulated the levels of TNFalpha (from 4974.75 +/- 875.78 to 1008 +/- 350 pg/hind paw), NGF (from 352.9 +/- 46.7 to 33.9 +/- 2.4 pg/hind paw) and IL-1beta (from 2773.88 +/- 423.96 to 1108 +/- 399.56 pg/hind paw). These data suggest that IL-10 inhibits ET-induced hyperalgesia by downregulation of TNFalpha, IL-1beta and NGF production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Endotoxins / pharmacology*
  • Hindlimb
  • Hot Temperature
  • Hyperalgesia / drug therapy*
  • Hyperalgesia / immunology*
  • Interleukin-1 / analysis
  • Interleukin-1 / metabolism
  • Interleukin-10 / pharmacology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Nerve Growth Factors / analysis
  • Nerve Growth Factors / metabolism
  • Nociceptors / drug effects
  • Nociceptors / physiology
  • Skin / chemistry
  • Skin / metabolism
  • Tumor Necrosis Factor-alpha / analysis
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Endotoxins
  • Interleukin-1
  • Nerve Growth Factors
  • Tumor Necrosis Factor-alpha
  • Interleukin-10