A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling

R Saunders; S R Nahorski; R A Challiss

doi:10.1016/s0028-3908(98)00027-6

A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling

Neuropharmacology. 1998;37(2):273-6. doi: 10.1016/s0028-3908(98)00027-6.

Authors

R Saunders¹, S R Nahorski, R A Challiss

Affiliation

¹ Department of Cell Physiology and Pharmacology, University of Leicester, UK.

PMID: 9680253
DOI: 10.1016/s0028-3908(98)00027-6

Abstract

Increasing [Ca2+]e from 1.3 4 mM had little effect on basal phospholipase C activity in baby hamster kidney (BHK) cells stably expressing either type 1alpha metabotropic glutamate (mGlu1alpha) or M3-muscarinic (m3) receptors, but enhanced agonist-stimulated phosphoinositide hydrolysis in BHK-mGlu1alpha, but not BHK-m3 cells, demonstrating that Ca2+(e) selectively modulates phosphoinositide signalling stimulated by this receptor subtype.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arecoline / pharmacology
Calcium / pharmacology*
Cell Line
Cricetinae
Cycloleucine / analogs & derivatives*
Cycloleucine / pharmacology
Enzyme Activation
Excitatory Amino Acid Agonists / pharmacology*
Inositol Phosphates / biosynthesis*
Kidney / drug effects
Kidney / physiology
Methacholine Chloride / pharmacology
Muscarinic Agonists / pharmacology
Quisqualic Acid / pharmacology*
Receptors, Metabotropic Glutamate / drug effects
Receptors, Metabotropic Glutamate / physiology*
Receptors, Muscarinic / drug effects
Type C Phospholipases / metabolism

Substances

Excitatory Amino Acid Agonists
Inositol Phosphates
Muscarinic Agonists
Receptors, Metabotropic Glutamate
Receptors, Muscarinic
metabotropic glutamate receptor type 1
Cycloleucine
Methacholine Chloride
1-amino-1,3-dicarboxycyclopentane
Arecoline
Quisqualic Acid
Type C Phospholipases
Calcium