Abstract
The medial nucleus of the trapezoid body (MNTB) in the superior olivary complex (SOC) is an inhibitory hub considered critical for binaural sound localization. We show that genetic ablation of MNTB neurons in mice only subtly affects this ability by prolonging the minimum time required to detect shifts in sound location. Furthermore, glycinergic innervation of the SOC is maintained without an MNTB, consistent with the existence of parallel inhibitory inputs. These findings redefine the role of MNTB in sound localization and suggest that the inhibitory network is more complex than previously thought.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
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Acoustic Stimulation
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Animals
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Animals, Newborn
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Auditory Pathways / physiology
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Early Growth Response Protein 2 / genetics
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Evoked Potentials, Auditory, Brain Stem / drug effects
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Evoked Potentials, Auditory, Brain Stem / genetics
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Excitatory Amino Acid Antagonists / pharmacology
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Functional Laterality
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Glycine / metabolism*
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Glycine Plasma Membrane Transport Proteins / metabolism
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Homeodomain Proteins / genetics
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In Vitro Techniques
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Inhibitory Postsynaptic Potentials / drug effects
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Inhibitory Postsynaptic Potentials / genetics
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Neural Inhibition / drug effects
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Neural Inhibition / genetics
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Neural Inhibition / physiology*
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Olivary Nucleus / cytology*
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Olivary Nucleus / physiology*
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Patch-Clamp Techniques
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Sound Localization / drug effects
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Sound Localization / physiology*
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Strychnine / pharmacology
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Valine / analogs & derivatives
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Valine / pharmacology
Substances
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Early Growth Response Protein 2
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Egr2 protein, mouse
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En1 protein, mouse
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Excitatory Amino Acid Antagonists
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Glycine Plasma Membrane Transport Proteins
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Homeodomain Proteins
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Slc6a5 protein, mouse
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6-Cyano-7-nitroquinoxaline-2,3-dione
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2-amino-5-phosphopentanoic acid
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Strychnine
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Valine
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Glycine