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Page 1
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.
Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU, Bloom GS. Nussbaum JM, et al. Among authors: graubner s. Nature. 2012 May 2;485(7400):651-5. doi: 10.1038/nature11060. Nature. 2012. PMID: 22660329 Free PMC article.
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S. Becker A, et al. Among authors: graubner s. Biol Chem. 2016 Jan;397(1):45-55. doi: 10.1515/hsz-2015-0192. Biol Chem. 2016. PMID: 26351917
Glutaminyl cyclases as novel targets for the treatment of septic arthritis.
Hellvard A, Maresz K, Schilling S, Graubner S, Heiser U, Jonsson R, Cynis H, Demuth HU, Potempa J, Mydel P. Hellvard A, et al. Among authors: graubner s. J Infect Dis. 2013 Mar 1;207(5):768-77. doi: 10.1093/infdis/jis729. Epub 2012 Nov 29. J Infect Dis. 2013. PMID: 23204180 Free PMC article.
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU. Cynis H, et al. Among authors: graubner s. EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20. EMBO Mol Med. 2011. PMID: 21774078 Free PMC article.
Optimizing the composition of a synthetic cellulosome complex for the hydrolysis of softwood pulp: identification of the enzymatic core functions and biochemical complex characterization.
Leis B, Held C, Andreeßen B, Liebl W, Graubner S, Schulte LP, Schwarz WH, Zverlov VV. Leis B, et al. Among authors: graubner s. Biotechnol Biofuels. 2018 Aug 9;11:220. doi: 10.1186/s13068-018-1220-y. eCollection 2018. Biotechnol Biofuels. 2018. PMID: 30116297 Free PMC article.
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.
Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S. Alexandru A, et al. Among authors: graubner s. J Neurosci. 2011 Sep 7;31(36):12790-801. doi: 10.1523/JNEUROSCI.1794-11.2011. J Neurosci. 2011. PMID: 21900558 Free PMC article.
Comparative characterization of all cellulosomal cellulases from Clostridium thermocellum reveals high diversity in endoglucanase product formation essential for complex activity.
Leis B, Held C, Bergkemper F, Dennemarck K, Steinbauer R, Reiter A, Mechelke M, Moerch M, Graubner S, Liebl W, Schwarz WH, Zverlov VV. Leis B, et al. Among authors: graubner s. Biotechnol Biofuels. 2017 Oct 23;10:240. doi: 10.1186/s13068-017-0928-4. eCollection 2017. Biotechnol Biofuels. 2017. PMID: 29075324 Free PMC article.
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
Jawhar S, Wirths O, Schilling S, Graubner S, Demuth HU, Bayer TA. Jawhar S, et al. Among authors: graubner s. J Biol Chem. 2011 Feb 11;286(6):4454-60. doi: 10.1074/jbc.M110.185819. Epub 2010 Dec 10. J Biol Chem. 2011. PMID: 21148560 Free PMC article.
Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU. Schilling S, et al. Among authors: graubner s. J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17. J Biol Chem. 2011. PMID: 21330373 Free PMC article.