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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1954 1
1957 1
1963 1
1965 1
1966 1
1967 1
1968 1
1969 2
1970 1
1973 3
1974 2
1975 4
1976 4
1977 10
1978 2
1979 5
1980 6
1981 6
1982 3
1983 5
1984 2
1985 2
1987 5
1988 3
1989 1
1990 6
1991 4
1992 4
1993 11
1994 9
1995 11
1996 9
1997 11
1998 13
1999 10
2000 6
2001 8
2002 6
2003 4
2004 4
2005 11
2006 6
2007 4
2008 4
2009 5
2010 5
2011 3
2012 7
2013 4
2014 4
2015 8
2016 8
2017 10
2018 5
2019 5
2020 10
2021 13
2022 8
2023 18
2024 4

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314 results

Results by year

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Page 1
A Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis.
Tuttle J, Drescher E, Simón-Campos JA, Emery P, Greenwald M, Kivitz A, Rha H, Yachi P, Kiley C, Nirula A. Tuttle J, et al. N Engl J Med. 2023 May 18;388(20):1853-1862. doi: 10.1056/NEJMoa2209856. N Engl J Med. 2023. PMID: 37195941 Free article. Clinical Trial.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Owen DR, Allerton CMN, Anderson AS, Aschenbrenner L, Avery M, Berritt S, Boras B, Cardin RD, Carlo A, Coffman KJ, Dantonio A, Di L, Eng H, Ferre R, Gajiwala KS, Gibson SA, Greasley SE, Hurst BL, Kadar EP, Kalgutkar AS, Lee JC, Lee J, Liu W, Mason SW, Noell S, Novak JJ, Obach RS, Ogilvie K, Patel NC, Pettersson M, Rai DK, Reese MR, Sammons MF, Sathish JG, Singh RSP, Steppan CM, Stewart AE, Tuttle JB, Updyke L, Verhoest PR, Wei L, Yang Q, Zhu Y. Owen DR, et al. Among authors: tuttle jb. Science. 2021 Dec 24;374(6575):1586-1593. doi: 10.1126/science.abl4784. Epub 2021 Nov 2. Science. 2021. PMID: 34726479 Free article.
Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Ulcerative Colitis.
Sandborn WJ, Ferrante M, Bhandari BR, Berliba E, Feagan BG, Hibi T, Tuttle JL, Klekotka P, Friedrich S, Durante M, Morgan-Cox M, Laskowski J, Schmitz J, D'Haens GR. Sandborn WJ, et al. Among authors: tuttle jl. Gastroenterology. 2020 Feb;158(3):537-549.e10. doi: 10.1053/j.gastro.2019.08.043. Epub 2019 Sep 4. Gastroenterology. 2020. PMID: 31493397 Free article. Clinical Trial.
Hemophilic Arthropathy.
Nacca CR, Harris AP, Tuttle JR. Nacca CR, et al. Among authors: tuttle jr. Orthopedics. 2017 Nov 1;40(6):e940-e946. doi: 10.3928/01477447-20170619-05. Epub 2017 Jun 30. Orthopedics. 2017. PMID: 28662249 Review.
Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Crohn's Disease.
Sands BE, Peyrin-Biroulet L, Kierkus J, Higgins PDR, Fischer M, Jairath V, Hirai F, D'Haens G, Belin RM, Miller D, Gomez-Valderas E, Naegeli AN, Tuttle JL, Pollack PF, Sandborn WJ. Sands BE, et al. Among authors: tuttle jl. Gastroenterology. 2022 Feb;162(2):495-508. doi: 10.1053/j.gastro.2021.10.050. Epub 2021 Nov 5. Gastroenterology. 2022. PMID: 34748774 Clinical Trial.
Mirikizumab Regulates Genes Involved in Ulcerative Colitis Disease Activity and Anti-TNF Resistance: Results From a Phase 2 Study.
Steere B, Schmitz J, Powell N, Higgs R, Gottlieb K, Liu Y, Jia B, Tuttle JL, Sandborn WJ, Sands BE, D'Haens G, Reinisch W, Krishnan V. Steere B, et al. Among authors: tuttle jl. Clin Transl Gastroenterol. 2023 Jul 1;14(7):e00578. doi: 10.14309/ctg.0000000000000578. Clin Transl Gastroenterol. 2023. PMID: 36881820 Free PMC article. Clinical Trial.
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Lees JA, Dias JM, Rajamohan F, Fortin JP, O'Connor R, Kong JX, Hughes EAG, Fisher EL, Tuttle JB, Lovett G, Kormos BL, Unwalla RJ, Zhang L, Dechert Schmitt AM, Zhou D, Moran M, Stevens KA, Fennell KF, Varghese AE, Maxwell A, Cote EE, Zhang Y, Han S. Lees JA, et al. Among authors: tuttle jb. Nat Commun. 2023 Sep 23;14(1):5938. doi: 10.1038/s41467-023-41646-3. Nat Commun. 2023. PMID: 37741852 Free PMC article.
Efficacy and Safety of Continued Treatment With Mirikizumab in a Phase 2 Trial of Patients With Ulcerative Colitis.
Sandborn WJ, Ferrante M, Bhandari BR, Berliba E, Hibi T, D'Haens GR, Tuttle JL, Krueger K, Friedrich S, Durante M, Arora V, Naegeli AN, Schmitz J, Feagan BG. Sandborn WJ, et al. Among authors: tuttle jl. Clin Gastroenterol Hepatol. 2022 Jan;20(1):105-115.e14. doi: 10.1016/j.cgh.2020.09.028. Epub 2020 Sep 18. Clin Gastroenterol Hepatol. 2022. PMID: 32950748 Free article. Clinical Trial.
Changes in health-related quality of life and associations with improvements in clinical efficacy: a Phase 2 study of mirikizumab in patients with ulcerative colitis.
Dubinsky MC, Jairath V, Feagan BG, Naegeli AN, Tuttle J, Morris N, Shan M, Arora V, Lissoos T, Agada N, Hibi T, Sands BE. Dubinsky MC, et al. Among authors: tuttle j. BMJ Open Gastroenterol. 2023 Mar;10(1):e001115. doi: 10.1136/bmjgast-2023-001115. BMJ Open Gastroenterol. 2023. PMID: 37001911 Free PMC article. Clinical Trial.
314 results