User profiles for A. B. Bowman

Aaron B. Bowman

Purdue University
Verified email at purdue.edu
Cited by 9771

Manganese is essential for neuronal health

…, SW Caito, KG Tipps, AB Bowman… - Annual review of …, 2015 - annualreviews.org
The understanding of manganese (Mn) biology, in particular its cellular regulation and role in
neurological disease, is an area of expanding interest. Mn is an essential micronutrient that …

Role of manganese in neurodegenerative diseases

AB Bowman, GF Kwakye, EH Hernández… - Journal of trace elements …, 2011 - Elsevier
… To identify metals that share pathophysiological mechanisms with HD and thus potentially
modify the age of disease onset, severity, and neuropathology, Bowman and colleagues …

[HTML][HTML] Manganese-induced parkinsonism and Parkinson's disease: shared and distinguishable features

…, S Mukhopadhyay, AB Bowman… - International journal of …, 2015 - mdpi.com
Manganese (Mn) is an essential trace element necessary for physiological processes that
support development, growth and neuronal function. Secondary to elevated exposure or …

Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2

…, J Crespo-Barreto, AB Bowman… - Proceedings of the …, 2005 - National Acad Sciences
Rett syndrome (RTT) is a postnatal neurodevelopmental disorder characterized by the loss
of acquired motor and language skills, autistic features, and unusual stereotyped movements…

[HTML][HTML] Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

…, LJ McCawley, JM May, DJ Webb, D Li, AB Bowman… - …, 2015 - pubs.aip.org
The blood-brain barrier (BBB) is a critical structure that serves as the gatekeeper between
the central nervous system and the rest of the body. It is the responsibility of the BBB to …

[HTML][HTML] Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein

AB Bowman, A Kamal, BW Ritchings, AV Philp… - Cell, 2000 - cell.com
A broadly conserved membrane-associated protein required for the functional interaction of
kinesin-I with axonal cargo was identified. Mutations in sunday driver (syd) and the axonal …

[HTML][HTML] ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology

YC Lam, AB Bowman, P Jafar-Nejad, J Lim, R Richman… - Cell, 2006 - cell.com
Spinocerebellar ataxia type 1 (SCA1) is one of several neurodegenerative diseases caused
by expansion of a polyglutamine tract in the disease protein, in this case, ATAXIN-1 (ATXN1)…

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

J Lim, J Crespo-Barreto, P Jafar-Nejad, AB Bowman… - Nature, 2008 - nature.com
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease
caused by expansion of a glutamine-encoding repeat in ataxin 1 (ATXN1). In all known …

[HTML][HTML] Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies

…, P Chen, F Carvalho, DS Avila, AB Bowman… - BMC Pharmacology and …, 2016 - Springer
Manganese (Mn) is an essential heavy metal. However, Mn’s nutritional aspects are paralleled
by its role as a neurotoxicant upon excessive exposure. In this review, we covered recent …

Manganese homeostasis in the nervous system

…, E Lee, MMB Paoliello, AB Bowman… - Journal of …, 2015 - Wiley Online Library
Manganese (Mn) is an essential heavy metal that is naturally found in the environment.
Daily intake through dietary sources provides the necessary amount required for several key …