Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors

M Melis, M Pistis, S Perra, AL Muntoni… - Journal of …, 2004 - Soc Neuroscience
The endogenous cannabinoid system has been shown to play a crucial role in controlling
neuronal excitability and synaptic transmission. In this study we investigated the effects of a …

Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors

GL Gessa, M Melis, AL Muntoni, M Diana - European journal of …, 1998 - Elsevier
The present study was designed to determine if cannabinoids share with other drugs of abuse
the ability to stimulate mesolimbic dopaminergic neurons and if this effect is mediated by …

Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons

M Melis, S Perra, AL Muntoni, G Pillolla… - Journal of …, 2004 - Soc Neuroscience
… According to previous studies (Tong et al., 1996a,b), this analysis revealed that a large
number of bursts were temporally associated with the occurrence of stimuli. Stimulus-evoked …

Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons

M Pistis, S Perra, G Pillolla, M Melis, AL Muntoni… - Biological …, 2004 - Elsevier
BACKGROUND: Recent studies have raised concerns about subtle long-lasting neurobiological
changes that might be triggered by exposure to Cannabis derivatives, especially in a …

[HTML][HTML] Inhibitory inputs from rostromedial tegmental neurons regulate spontaneous activity of midbrain dopamine cells and their responses to drugs of abuse

S Lecca, M Melis, A Luchicchi, AL Muntoni… - …, 2012 - nature.com
The rostromedial tegmental nucleus (RMTg), a structure located just posterior to the ventral
tegmental area (VTA), is an important site involved in aversion processes. The RMTg …

Mesolimbic dopaminergic decline after cannabinoid withdrawal

M Diana, M Melis, AL Muntoni… - Proceedings of the …, 1998 - National Acad Sciences
The mesolimbic dopamine system has recently been implicated in the long-term aversive
consequences of withdrawal from major drugs of abuse. In the present study we sought to …

Endocannabinoid signaling in motivation, reward, and addiction: influences on mesocorticolimbic dopamine function

C Sagheddu, AL Muntoni, M Pistis, M Melis - International review of …, 2015 - Elsevier
Evidence suggests that the endocannabinoid system has been conserved in the animal
kingdom for 500 million years, and this system influences many critical behavioral processes …

Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors

M Melis, G Pillolla, A Luchicchi, AL Muntoni… - Journal of …, 2008 - Soc Neuroscience
Nicotine stimulates the activity of mesolimbic dopamine neurons, which is believed to mediate
the rewarding and addictive properties of tobacco use. Accumulating evidence suggests …

[HTML][HTML] Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells

…, MG Ennas, MP Castelli, AL Muntoni… - …, 2011 - nature.com
Recent findings have underlined the rostromedial tegmental nucleus (RMTg), a structure
located caudally to the ventral tegmental area, as an important site involved in the mechanisms …

[HTML][HTML] Repurposing peroxisome proliferator-activated receptor agonists in neurological and psychiatric disorders

C Sagheddu, M Melis, AL Muntoni, M Pistis - Pharmaceuticals, 2021 - mdpi.com
Common pathophysiological mechanisms have emerged for different neurological and
neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno-inflammation, …