Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors
The endogenous cannabinoid system has been shown to play a crucial role in controlling
neuronal excitability and synaptic transmission. In this study we investigated the effects of a …
neuronal excitability and synaptic transmission. In this study we investigated the effects of a …
Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors
The present study was designed to determine if cannabinoids share with other drugs of abuse
the ability to stimulate mesolimbic dopaminergic neurons and if this effect is mediated by …
the ability to stimulate mesolimbic dopaminergic neurons and if this effect is mediated by …
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons
M Melis, S Perra, AL Muntoni, G Pillolla… - Journal of …, 2004 - Soc Neuroscience
… According to previous studies (Tong et al., 1996a,b), this analysis revealed that a large
number of bursts were temporally associated with the occurrence of stimuli. Stimulus-evoked …
number of bursts were temporally associated with the occurrence of stimuli. Stimulus-evoked …
Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons
BACKGROUND: Recent studies have raised concerns about subtle long-lasting neurobiological
changes that might be triggered by exposure to Cannabis derivatives, especially in a …
changes that might be triggered by exposure to Cannabis derivatives, especially in a …
[HTML][HTML] Inhibitory inputs from rostromedial tegmental neurons regulate spontaneous activity of midbrain dopamine cells and their responses to drugs of abuse
The rostromedial tegmental nucleus (RMTg), a structure located just posterior to the ventral
tegmental area (VTA), is an important site involved in aversion processes. The RMTg …
tegmental area (VTA), is an important site involved in aversion processes. The RMTg …
Mesolimbic dopaminergic decline after cannabinoid withdrawal
The mesolimbic dopamine system has recently been implicated in the long-term aversive
consequences of withdrawal from major drugs of abuse. In the present study we sought to …
consequences of withdrawal from major drugs of abuse. In the present study we sought to …
Endocannabinoid signaling in motivation, reward, and addiction: influences on mesocorticolimbic dopamine function
Evidence suggests that the endocannabinoid system has been conserved in the animal
kingdom for 500 million years, and this system influences many critical behavioral processes …
kingdom for 500 million years, and this system influences many critical behavioral processes …
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors
M Melis, G Pillolla, A Luchicchi, AL Muntoni… - Journal of …, 2008 - Soc Neuroscience
Nicotine stimulates the activity of mesolimbic dopamine neurons, which is believed to mediate
the rewarding and addictive properties of tobacco use. Accumulating evidence suggests …
the rewarding and addictive properties of tobacco use. Accumulating evidence suggests …
[HTML][HTML] Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells
…, MG Ennas, MP Castelli, AL Muntoni… - …, 2011 - nature.com
Recent findings have underlined the rostromedial tegmental nucleus (RMTg), a structure
located caudally to the ventral tegmental area, as an important site involved in the mechanisms …
located caudally to the ventral tegmental area, as an important site involved in the mechanisms …
[HTML][HTML] Repurposing peroxisome proliferator-activated receptor agonists in neurological and psychiatric disorders
C Sagheddu, M Melis, AL Muntoni, M Pistis - Pharmaceuticals, 2021 - mdpi.com
Common pathophysiological mechanisms have emerged for different neurological and
neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno-inflammation, …
neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno-inflammation, …