Increasing numbers of healthcare professionals are using smartphones and their associated
applications (apps) in daily clinical care. While these medical apps hold great potential for …

Subcortical structures are a relative neurophysiological ‘terra incognita’ owing to their location
within the skull. While perioperative subcortical sensing has been performed for more …

Background: Tremor is the most prevalent movement disorder in clinical practice. It is defined
as involuntary, rhythmic, oscillatory movements. The diagnostic process of patients with …

… Buijink AW, van der Stouwe AMM, Broersma M, et al. Motor network disruption in
essential tremor: a functional and effective connectivity study. Brain 2015; 138:2934–2947 …

Introduction Cerebellar circuits are hypothesized to play a central role in the pathogenesis of
essential tremor. Rhythmic finger tapping is known to strongly engage the cerebellar motor …

Although involvement of the cerebello-thalamo-cortical network has often been suggested
in essential tremor, the source of oscillatory activity remains largely unknown. To elucidate …

Dystonic tremor syndromes are highly burdensome and treatment is often inadequate. This
is partly due to poor understanding of the underlying pathophysiology. Several lines of …

Background Essential tremor (ET) is one of the most common hyperkinetic movement
disorders. Previous research into the pathophysiology of ET suggested underlying cerebellar …

Pathophysiology of tremor generation remains uncertain in ‘familial cortical myoclonic
tremor with epilepsy’ (FCMTE) and essential tremor (ET). In both disorders, imaging and …

Action selection describes the high-level process that selects between competing movements.
In animals, behavioral variability is critical for the motor exploration required to select the …