Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …

Mutations were identified in the Cu/Zn superoxide dismutase gene (SOD1) in ∼15% of patients
with familial amyotrophic lateral sclerosis. Transgenic animals expressing mutant SOD1 …

The complex relationship between metabolic disease risk and body fat distribution in humans
involves cellular characteristics that are specific to body fat compartments. Here we show …

Mutations in the Cu/Zn superoxide dismutase (SODl) gene are found in 15 to 20% of
patients with familial amyotrophic lateral sclerosis (FALS). Increased levels of neurofilament …

The Reelin signaling cascade plays a crucial role in the correct positioning of neurons
during embryonic brain development. Reelin binding to apolipoprotein E receptor 2 (ApoER2) …

Humans display remarkable interindividual variation in their immune response to identical
challenges. Yet, our understanding of the genetic and epigenetic factors contributing to such …

Embryonal tumors with multilayered rosettes (ETMRs) are rare, deadly pediatric brain
tumors characterized by high-level amplification of the microRNA cluster C19MC 1 , 2 . We …

The reelin signaling pathway regulates nervous system function after birth, in addition to its
role in regulating neuronal positioning during embryogenesis. The receptor-dependent, reelin…

The tyrosine phosphorylation sites of the Disabled 1 (Dab1) docking protein are essential for
the transmission of the Reelin signal, which regulates neuronal placement. Here we identify …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting motor
neurons. Although most cases of ALS are sporadic, approximately 10% are inherited as an …