The amyloid proteins isolated from neuritic plaques and the cerebrovasculature of Alzheimer's
disease are self-aggregating moieties termed A4 protein1 and βprotein 2,3 , respectively. …

Transgenic mice overexpressing different forms of amyloid precursor protein (APP), ie wild
type or clinical mutants, displayed an essentially comparable early phenotype in terms of …

… B-APP. There are at least six different mRNA transcripts produced by splice variants of the
B-APP … Four of these isoforms (695, 714, 751 and 770 amino acids in length) contain the B-A4 …

… The resultant molecule, proinsulin, in which the peptides B and A are joined by the
connecting C-peptide (NH,-BCA-COOH), is the precursor of insulin". The connecting peptide is …

DEPOSITS of β-amyloid are one of the main pathological charac-teristics of Alzheimer's
disease. The β-amyloid peptide constituent (relative molecular mass 4,200) of the deposits is …

Background Inflammation plays a central role in cardiometabolic disease and may
represent a mechanism linking low socioeconomic status (SES) in early life and adverse …

… Further studies will be required to demonstrate whether or not a direct causal relationship
exists between ,B-A4 deposition and/or aberrant tau and the cognitive deficits we have …

Mutations of presenilin 1 (PS1) causing Alzheimer's disease selectively increase the secretion
of the amyloidogenic βA4(1-42), whereas knocking out the gene results in decreased …

Presenilins are integral membrane protein involved in the production of amyloid β-protein.
Mutations of the presenilin-1 and -2 gene are associated with familial Alzheimer's disease …

… A single positive clone, pHS-6, was isolated and further characterized by nucleotide sequence
analysis, b, An adult lung cDNA library was obtained from Dr Barry Greenberg. Starting …