Diffusion in brain extracellular space
E Syková, C Nicholson - Physiological reviews, 2008 - journals.physiology.org
… by Nicholson and Syková (264) still provides a useful overview on the use of diffusion to
explore structure, and a longer review by Nicholson (… The concentrations C and C 1 are simply …
explore structure, and a longer review by Nicholson (… The concentrations C and C 1 are simply …
Clearance systems in the brain—implications for Alzheimer disease
Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and hyperphosphorylated
tau tangles—is the pathological hallmark of Alzheimer disease (AD). Aβ accumulation has …
tau tangles—is the pathological hallmark of Alzheimer disease (AD). Aβ accumulation has …
Extracellular space structure revealed by diffusion analysis
C Nicholson, E Syková - Trends in neurosciences, 1998 - cell.com
The structure of brain extracellular space resembles foam. Diffusing molecules execute
random movements that cause their collision with membranes and affect their concentration …
random movements that cause their collision with membranes and affect their concentration …
Sleep drives metabolite clearance from the adult brain
…, J O'Donnell, DJ Christensen, C Nicholson… - science, 2013 - science.org
… Because Aβ is also removed from CNS via receptor-mediated transport across the blood-brain
barrier (24), we also analyzed the clearance of an inert tracer, 14 C-inulin. C-inulin was …
barrier (24), we also analyzed the clearance of an inert tracer, 14 C-inulin. C-inulin was …
[HTML][HTML] The Medicago genome provides insight into the evolution of rhizobial symbioses
Legumes (Fabaceae or Leguminosae) are unique among cultivated plants for their ability to
carry out endosymbiotic nitrogen fixation with rhizobial bacteria, a process that takes place …
carry out endosymbiotic nitrogen fixation with rhizobial bacteria, a process that takes place …
Searching for an operational definition of frailty: a Delphi method based consensus statement. The frailty operative definition-consensus conference project
…, H Bergman, L Carcaillon, C Nicholson… - … of gerontology series …, 2013 - academic.oup.com
Background. There is no consensus regarding the definition of frailty for clinical uses. Methods.
A modified Delphi process was used to attempt to achieve consensus definition. Experts …
A modified Delphi process was used to attempt to achieve consensus definition. Experts …
Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine
…, R Mehta, S Nadel, T Nguyen, C Nicholson… - Critical care …, 2009 - journals.lww.com
Background: The Institute of Medicine calls for the use of clinical guidelines and practice
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …
[BOOK][B] The central nervous system of vertebrates
R Nieuwenhuys, HJ Ten Donkelaar, C Nicholson - 2014 - books.google.com
… In the early 1970s Charles Nicholson was invited to join the project. Some years earlier
he and Rudolf Nieuwenhuys had collaborated on a study of the structure of the mormyrid …
he and Rudolf Nieuwenhuys had collaborated on a study of the structure of the mormyrid …
Predictors of mortality in hospitalized COVID‐19 patients: a systematic review and meta‐analysis
Mortality rates of coronavirus disease‐2019 (COVID‐19) continue to rise across the world.
Information regarding the predictors of mortality in patients with COVID‐19 remains scarce. …
Information regarding the predictors of mortality in patients with COVID‐19 remains scarce. …
Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum.
C Nicholson, JM Phillips - The Journal of physiology, 1981 - Wiley Online Library
… Obviously as a becomes small, <C0>0 and C tend to equality and we shall show in the
Appendix that under our experimental conditions these two quantities are virtually identical. We …
Appendix that under our experimental conditions these two quantities are virtually identical. We …