PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

Tumor necrosis factor/cachectin (TNF) is a mediator of the septic state, which involves
diffuse abnormalities of coagulation throughout the vasculature. Since previous studies have …

… Frequently, the biology of RAGE coincides with settings in which ligands of the receptor
accumulate, especially in a proinflammatory environment such as diabetes mellitus, …

The receptor for advanced glycation end products (RAGE), a multi-ligand member of the
immunoglobulin superfamily of cell surface molecules 1 , 2 , interacts with distinct molecules …

AGEs Tumor biology Amphoterin albumin prepared in vitro (7). Its extracellular domain
consists of three immunoglobulin-like regions, one “V”-type followed by two “C”-type (8). RAGE …

Engagement of the receptor for advanced glycation end products (RAGE) by products of
nonenzymatic glycation/oxidation triggers the generation of reactive oxygen species (ROS), …

Activation of the transcription factor nuclear factor-κB (NF-κB) has been suggested to participate
in chronic disorders, such as diabetes and its complications. In contrast to the short and …

Thrombo-occlusive cerebrovascular disease resulting in stroke and permanent neuronal
loss is an important cause of morbidity and mortality. Because of the unique properties of …

Receptor for advanced glycation end products (RAGE) is a multiligand member of the
immunoglobulin superfamily of cell surface molecules whose repertoire of ligands includes …

Diabetic nephropathy ensues from events involving earliest changes in the glomeruli and
podocytes, followed by accumulation of extracellular matrix in the mesangium. Postulated …