User profiles for D. Guschin

Dmitry Guschin

Nazarbayev University, School of Medicine
Verified email at nu.edu.kz
Cited by 15118

Chromatin structural features and targets that regulate transcription

AP Wolffe, D Guschin - Journal of structural biology, 2000 - Elsevier
The nucleosome and chromatin fiber provide the common structural framework for transcriptional
control in eukaryotes. The folding of DNA within these structures can both promote and …

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

…, G Lee, VV Bartsevich, YL Lee, DY Guschin… - Nature …, 2008 - nature.com
Homozygosity for the naturally occurring Δ32 deletion in the HIV co-receptor CCR5 confers
resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using …

An improved zinc-finger nuclease architecture for highly specific genome editing

JC Miller, MC Holmes, J Wang, DY Guschin… - Nature …, 2007 - nature.com
Genome editing driven by zinc-finger nucleases (ZFNs) yields high gene-modification
efficiencies (>10%) by introducing a recombinogenic double-strand break into the targeted gene. …

[HTML][HTML] Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

…, LI Golbe, RH Myers, S Lindquist, L Zhang, D Guschin… - Cell, 2011 - cell.com
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a
unique tool for the study of human disease, as well as a promising source for cell …

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and-γ signal transduction

M Müller, J Briscoe, C Laxton, D Guschin, A Ziemiecki… - Nature, 1993 - nature.com
D, E, Tyrosine phosphorylation of JAK1 in mutant U1D which lacks Tyk2 (D) and in mutant
71A which lacks JAK2 (E). In each case data for the correSpOnding wild-type cells are …

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6.

D Guschin, N Rogers, J Briscoe, B Witthuhn… - The EMBO …, 1995 - embopress.org
The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and
activators of transcription) 1 and 3 are activated in response to interleukin‐6 (IL‐6) in human …

A rapid and general assay for monitoring endogenous gene modification

DY Guschin, AJ Waite, GE Katibah, JC Miller… - Engineered Zinc Finger …, 2010 - Springer
The development of zinc finger nucleases for targeted gene modification can benefit from
rapid functional assays that directly quantify activity at the endogenous target. Here we …

JAKs, STATs and signal transduction in response to the interferons and other cytokines

…, D Guschin, NC Rogers, D Watling… - … of the Royal …, 1996 - royalsocietypublishing.org
The isolation and complementation of mutant human cell lines has established an essential
role for the JAK (Janus kinase) family of protein tyrosine kinases and STAT (signal …

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

…, FD Urnov, MC Holmes, D Guschin… - Proceedings of the …, 2008 - National Acad Sciences
Gene knockout is the most powerful tool for determining gene function or permanently modifying
the phenotypic characteristics of a cell. Existing methods for gene disruption are limited …

DNA analysis and diagnostics on oligonucleotide microchips.

…, I Ivanov, S Parinov, D Guschin… - Proceedings of the …, 1996 - National Acad Sciences
We present a further development in the technology of sequencing by hybridization to
oligonucleotide microchips (SHOM) and its application to diagnostics for genetic diseases. A robot …