User profiles for D. Guschin
Dmitry GuschinNazarbayev University, School of Medicine Verified email at nu.edu.kz Cited by 15118 |
Chromatin structural features and targets that regulate transcription
AP Wolffe, D Guschin - Journal of structural biology, 2000 - Elsevier
The nucleosome and chromatin fiber provide the common structural framework for transcriptional
control in eukaryotes. The folding of DNA within these structures can both promote and …
control in eukaryotes. The folding of DNA within these structures can both promote and …
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
…, G Lee, VV Bartsevich, YL Lee, DY Guschin… - Nature …, 2008 - nature.com
Homozygosity for the naturally occurring Δ32 deletion in the HIV co-receptor CCR5 confers
resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using …
resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using …
An improved zinc-finger nuclease architecture for highly specific genome editing
Genome editing driven by zinc-finger nucleases (ZFNs) yields high gene-modification
efficiencies (>10%) by introducing a recombinogenic double-strand break into the targeted gene. …
efficiencies (>10%) by introducing a recombinogenic double-strand break into the targeted gene. …
[HTML][HTML] Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a
unique tool for the study of human disease, as well as a promising source for cell …
unique tool for the study of human disease, as well as a promising source for cell …
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and-γ signal transduction
… D, E, Tyrosine phosphorylation of JAK1 in mutant U1D which lacks Tyk2 (D) and in mutant
71A which lacks JAK2 (E). In each case data for the correSpOnding wild-type cells are …
71A which lacks JAK2 (E). In each case data for the correSpOnding wild-type cells are …
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6.
The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and
activators of transcription) 1 and 3 are activated in response to interleukin‐6 (IL‐6) in human …
activators of transcription) 1 and 3 are activated in response to interleukin‐6 (IL‐6) in human …
A rapid and general assay for monitoring endogenous gene modification
The development of zinc finger nucleases for targeted gene modification can benefit from
rapid functional assays that directly quantify activity at the endogenous target. Here we …
rapid functional assays that directly quantify activity at the endogenous target. Here we …
JAKs, STATs and signal transduction in response to the interferons and other cytokines
The isolation and complementation of mutant human cell lines has established an essential
role for the JAK (Janus kinase) family of protein tyrosine kinases and STAT (signal …
role for the JAK (Janus kinase) family of protein tyrosine kinases and STAT (signal …
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases
Gene knockout is the most powerful tool for determining gene function or permanently modifying
the phenotypic characteristics of a cell. Existing methods for gene disruption are limited …
the phenotypic characteristics of a cell. Existing methods for gene disruption are limited …
DNA analysis and diagnostics on oligonucleotide microchips.
…, I Ivanov, S Parinov, D Guschin… - Proceedings of the …, 1996 - National Acad Sciences
We present a further development in the technology of sequencing by hybridization to
oligonucleotide microchips (SHOM) and its application to diagnostics for genetic diseases. A robot …
oligonucleotide microchips (SHOM) and its application to diagnostics for genetic diseases. A robot …