Rapid actions of estrogens were first described >40 years ago. However, the importance of
rapid estrogen-mediated actions in the CNS is only now becoming apparent. Several lines of …

Estrogen’s acute, facilitatory effects on glutamatergic transmission and long-term potentiation
(LTP) provide a potential explanation for the steroid’s considerable influence on behavior. …

The fundamental observation that the temporal spacing of learning episodes plays a critical
role in the efficiency of memory encoding has had little effect on either research on long-term …

Brain-derived neurotrophic factor (BDNF) is an extremely potent, positive modulator of theta
burst induced long-term potentiation (LTP) in the adult hippocampus. The present studies …

Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms
and testing interventions and therapeutics. For disorders such as Alzheimer’s disease in …

Estrogen, in addition to its genomic effects in brain, causes rapid and reversible changes to
synaptic operations. We report here that these acute actions are due to selective activation of …

Evolving evidence suggests that brain inflammation and the buildup of proinflammatory
cytokine increases the risk for cognitive decline and cognitive dysfunction. Interleukin-1β (IL-1β), …

Microglia, the resident immune cell of the brain, can be eliminated via pharmacological
inhibition of the colony‐stimulating factor 1 receptor (CSF1R). Withdrawal of CSF1R inhibition …

Recent exome sequencing studies have implicated polymorphic Brg1-Associated Factor (BAF)
complexes (mammalian SWI/SNF chromatin remodeling complexes) in several human …

Reorganization of the actin cytoskeleton is essential for synaptic plasticity and memory
formation. Presently, the mechanisms that trigger actin dynamics during these brain processes …