User profiles for E. J. Huang
Eric J. HuangProfessor of Pathology & Vice Chair for Research, University of California San Francisco Verified email at ucsf.edu Cited by 36803 |
Neurotrophins: roles in neuronal development and function
EJ Huang, LF Reichardt - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …
Trk receptors: roles in neuronal signal transduction
EJ Huang, LF Reichardt - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …
The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis
P Besmer, K Manova, R Duttlinger, EJ Huang… - …, 1993 - journals.biologists.com
The c-kit receptor tyrosine kinase belongs to the PDGF/CSF-l/c-kit receptor subfamily. The kit
ligand, KL, also called steel factor, is synthesized from two alternatively spliced mRNAs as …
ligand, KL, also called steel factor, is synthesized from two alternatively spliced mRNAs as …
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the
adult mammalian hippocampus 1 , 2 , 3 , 4 , 5 . This process has been linked to learning and …
adult mammalian hippocampus 1 , 2 , 3 , 4 , 5 . This process has been linked to learning and …
[PDF][PDF] Acetylation of tau inhibits its degradation and contributes to tauopathy
Neurodegenerative tauopathies characterized by hyperphosphorylated tau include
frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and Alzheimer's …
frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and Alzheimer's …
[PDF][PDF] Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation
Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons
Defects in DNA repair have been extensively linked to neurodegenerative diseases, but the
exact mechanisms remain poorly understood. We found that FUS, an RNA/DNA-binding …
exact mechanisms remain poorly understood. We found that FUS, an RNA/DNA-binding …
The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features
…, LT Grinberg, AJ Rozemuller, EJ Huang… - Brain, 2015 - academic.oup.com
A ‘frontal variant of Alzheimer’s disease’ has been described in patients with predominant
behavioural or dysexecutive deficits caused by Alzheimer’s disease pathology. The …
behavioural or dysexecutive deficits caused by Alzheimer’s disease pathology. The …
Clinicopathological correlations in corticobasal degeneration
Objective: To characterize cognitive and behavioral features, physical findings, and brain
atrophy patterns in pathology‐proven corticobasal degeneration (CBD) and corticobasal …
atrophy patterns in pathology‐proven corticobasal degeneration (CBD) and corticobasal …
A dramatic increase of C1q protein in the CNS during normal aging
…, L Coutellier, L Kim, HH Tsai, EJ Huang… - Journal of …, 2013 - Soc Neuroscience
The decline of cognitive function has emerged as one of the greatest health threats of old
age. Age-related cognitive decline is caused by an impacted neuronal circuitry, yet the …
age. Age-related cognitive decline is caused by an impacted neuronal circuitry, yet the …