Experience‐dependent neural plasticity, learning, and memory in the era of epitranscriptomics

LJ Leighton, K Ke, EL Zajaczkowski… - Genes, Brain and …, 2018 - Wiley Online Library
In this short review, we highlight recent findings in the emerging field of epitranscriptomic
mechanisms and discuss their potential role in neural plasticity, learning and memory. These …

[PDF][PDF] ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

…, D Basic, H Ren, PR Marshall, EL Zajaczkowski… - Cell reports, 2022 - cell.com
Here, we used RNA capture-seq to identify a large population of lncRNAs that are expressed
in the infralimbic prefrontal cortex of adult male mice in response to fear-related learning. …

[HTML][HTML] Fear extinction is regulated by the activity of long noncoding RNAs at the synapse

…, SU Madugalle, EL Zajaczkowski… - Nature …, 2023 - nature.com
Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules
that are involved in many aspects of brain function. Emerging evidence indicates that …

The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

…, CB Vågbø, LJ Leighton, EL Zajaczkowski… - Nature …, 2019 - nature.com
DNA modification is known to regulate experience-dependent gene expression. However,
beyond cytosine methylation and its oxidated derivatives, very little is known about the …

Circular RNAs in the brain: a possible role in memory?

EL Zajaczkowski, TW Bredy - The Neuroscientist, 2021 - journals.sagepub.com
Higher-order organisms possess information processing capabilities that are only made
possible by their biological complexity. Emerging evidence indicates a critical role for regulatory …

Synapse-enriched m6A-modified Malat1 interacts with the novel m6A reader, DPYSL2, and is required for fear-extinction memory

…, A Periyakaruppiah, EL Zajaczkowski… - Journal of …, 2023 - Soc Neuroscience
The RNA modification N 6 -methyladenosine (m 6 A) regulates the interaction between RNA
and various RNA binding proteins within the nucleus and other subcellular compartments …

The DNA repair-associated protein Gadd45γ regulates the temporal coding of immediate early gene expression within the prelimbic prefrontal cortex and is required …

…, LJ Leighton, EL Zajaczkowski… - Journal of …, 2019 - Soc Neuroscience
We have identified a member of the growth arrest and DNA damage (Gadd45) protein family,
Gadd45γ, which is known to be critically involved in DNA repair, as a key player in the …

Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice

…, PR Marshall, VS Ratnu, X Li, EL Zajaczkowski… - Neurobiology of learning …, 2019 - Elsevier
The Piwi pathway is a conserved gene regulatory mechanism comprised of Piwi-like proteins
and Piwi-interacting RNAs, which modulates gene expression via RNA interference and …

Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

…, X Li, W Wei, A Periyakaruppiah, EL Zajaczkowski… - Nature …, 2020 - nature.com
DNA forms conformational states beyond the right-handed double helix; however, the
functional relevance of these noncanonical structures in the brain remains unknown. Here we …

Bioorthogonal metabolic labeling of nascent RNA in neurons improves the sensitivity of transcriptome-wide profiling

EL Zajaczkowski, QY Zhao, ZH Zhang… - ACS chemical …, 2018 - ACS Publications
Transcriptome-wide expression profiling of neurons has provided important insights into the
underlying molecular mechanisms and gene expression patterns that transpire during …