The major drainage structures for aqueous humor (AH) are the conventional or trabecular
outflow pathways, which are comprised of the trabecular meshwork (made up by the uveal and …

During development of the anterior eye segment, cells that originate from the surface epithelium
or the neuroepithelium need to interact with mesenchymal cells, which predominantly …

purpose. To study the role of αB-crystallin (αB) in the developing lens and its importance in
lens structure and function. methods. Gene targeting in embryonic stem cells was used to …

The high-mobility-group domain-containing transcription factor Sox11 is expressed transiently
during embryonic development in many tissues that undergo inductive remodeling. Here …

… (Tamm 2009a). From there, the aqueous humor flows to the anterior chamber to leave it
through the trabecular meshwork outflow pathways in the iridocorneal angle of the eye (Tamm …

Mutations in the transcription factor SOX10 cause neurocristopathies, including
Waardenburg-Hirschsprung syndrome and peripheral neuropathies in humans. This is partly …

Mutations in the MYOC gene that encodes for myocilin are causative for some forms of
juvenile and adult-onset primary open-angle glaucoma (POAG). Myocilin is a secreted 55–57kDa …

Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular
mechanisms involved in the regulation of conventional outflow resistance and thus intraocular …

Myelin is essential for rapid saltatory conduction and is produced by Schwann cells in the
peripheral nervous system and oligodendrocytes in the central nervous system. In both cell …

The most critical risk factor for optic nerve damage in cases of primary open-angle glaucoma
(POAG) is an increased intraocular pressure (IOP) caused by a resistance to aqueous …