Apoptosis and the cell cycle
Apoptosis is an evolutionarily conserved ‘suicide’ programme present in all metazoan cells.
Despite its highly conserved nature, it is only recently that any of the molecular mechanisms …
Despite its highly conserved nature, it is only recently that any of the molecular mechanisms …
Evaluating robustness and sensitivity of the NanoString technologies nCounter platform to enable multiplexed gene expression analysis of clinical samples
…, A Sharpe, M Dymond, JC Barrett, EA Harrington… - Cancer research, 2015 - AACR
Abstract Analysis of clinical trial specimens such as formalin-fixed paraffin-embedded (FFPE)
tissue for molecular mechanisms of disease progression or drug response is often …
tissue for molecular mechanisms of disease progression or drug response is often …
Overcoming remyelination failure in multiple sclerosis and other myelin disorders
Protecting axons from degeneration represents a major unmet need in the treatment of
myelin disorders and especially the currently untreatable secondary progressive stages of …
myelin disorders and especially the currently untreatable secondary progressive stages of …
Cuspal movement and microleakage in premolar teeth restored with a packable composite cured in bulk or in increments
G Abbas, GJP Fleming, E Harrington, ACC Shortall… - Journal of dentistry, 2003 - Elsevier
Introduction. The aim of this study was to investigate the effect of two novel curing systems (a
plasma arc light, and a ‘turbo-boosted’ conventional curing light) on cuspal movement and …
plasma arc light, and a ‘turbo-boosted’ conventional curing light) on cuspal movement and …
Shopfloor innovation: Facilitating the suggestion and implementation of ideas
…, TD Wall, PE Waterson, E Harrington - … of occupational and …, 2000 - Wiley Online Library
Despite increasing recognition of the importance of fostering innovation among shopfloor
employees, little empirical research has been conducted on the topic. Moreover, within work …
employees, little empirical research has been conducted on the topic. Moreover, within work …
[HTML][HTML] HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation …
…, I Borrello, JD Powell, E Harrington… - Biology of Blood and …, 2008 - Elsevier
We evaluated the safety and efficacy of high-dose, posttransplantation cyclophosphamide (Cy)
to prevent graft rejection and graft-versus-host disease (GVHD) after outpatient …
to prevent graft rejection and graft-versus-host disease (GVHD) after outpatient …
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
EA Harrington, D Bebbington, J Moore… - Nature medicine, 2004 - nature.com
The Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis
during mitosis. Aberrant expression and activity of these kinases occur in a wide range …
during mitosis. Aberrant expression and activity of these kinases occur in a wide range …
Induction of apoptosis by the Bcl-2 homologue Bak
T Chittenden, EA Harrington, R O'Connor… - Nature, 1995 - nature.com
… proteins that bind El B 19K and the colocalization of nuclear lamina" indicates that E1B 19K
has additional cellular targets, so we are also investigating which of these is essential for E …
has additional cellular targets, so we are also investigating which of these is essential for E …
Cooperative interaction between c-myc and bcl-2 proto-oncogenes
A Fanidi, EA Harrington, GI Evan - Nature, 1992 - nature.com
THE bcl-2 proto-oncogene is activated by translocation in a variety of B-lymphoid tumours and
synergizes with the c-myc oncogene in tumour progression 1 . The mechanism of synergy …
synergizes with the c-myc oncogene in tumour progression 1 . The mechanism of synergy …
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
…, C Luu, I Cornella-Taracido, E Harrington… - Nature cell …, 2014 - nature.com
Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain
cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for …
cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for …