Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …
essential for cellular homeostasis, development, and stress responsiveness. In response to …
New insights into IGF-1 signaling in the heart
Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy,
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …
Reactive oxygen species and calcium signals in skeletal muscle: a crosstalk involved in both normal signaling and disease
… Excitation-contraction coupling (E–C coupling) is followed by an adaptive change in
gene expression named excitation-transcription coupling [9], [10]. Thus, changes in gene …
gene expression named excitation-transcription coupling [9], [10]. Thus, changes in gene …
Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells
M Estrada, A Espinosa, M Müller, E Jaimovich - Endocrinology, 2003 - academic.oup.com
Involvement of intracellular Ca 2+ and ERK1/2 phosphorylation in the fast nongenomic effects
of androgens in myotubes was investigated. Testosterone or nandrolone produced fast (<…
of androgens in myotubes was investigated. Testosterone or nandrolone produced fast (<…
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
…, A Garcia, S Härtel, E Jaimovich… - Cardiovascular …, 2008 - academic.oup.com
… As illustrated in Figure 5D–E, DNA fragmentation and LDH activity levels did not change
with C 2 -ceramide. These data suggest that ceramides did not stimulate cell death by necrosis …
with C 2 -ceramide. These data suggest that ceramides did not stimulate cell death by necrosis …
[HTML][HTML] Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Reactive oxygen species (ROS) act as intracellular compartmentalized second messengers,
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …
[HTML][HTML] ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle
ATP released from cells is known to activate plasma membrane P2X (ionotropic) or P2Y (metabotropic)
receptors. In skeletal muscle cells, depolarizing stimuli induce both a fast calcium …
receptors. In skeletal muscle cells, depolarizing stimuli induce both a fast calcium …
Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS‐elicited Ca2+ stimulates ERK, CREB, early genes
…, M Angélica Carrasco, E Jaimovich - Journal of cellular …, 2006 - Wiley Online Library
… Angélica Carrasco and Enrique Jaimovich have contributed equally to this work. … E: series
of fluo-3 fluorescence images from a myotube taken at indicated times after H 2 O 2 (100 µM) …
of fluo-3 fluorescence images from a myotube taken at indicated times after H 2 O 2 (100 µM) …
Testosterone signals through mTOR and androgen receptor to induce muscle hypertrophy.
Purpose The anabolic hormone testosterone induces muscle hypertrophy, but the intracellular
mechanisms involved are poorly known. We addressed the question whether signal …
mechanisms involved are poorly known. We addressed the question whether signal …
Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kγ-Akt-AS160 in skeletal muscle cells
Skeletal muscle glucose uptake in response to exercise is preserved in insulin-resistant
conditions, but the signals involved are debated. ATP is released from skeletal muscle by …
conditions, but the signals involved are debated. ATP is released from skeletal muscle by …