Hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one the main
pathologic hallmarks in Alzheimer's disease (AD) and other tauopathies, including Pick's …

Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in
several physiological and pathological states, including Alzheimer’s disease (AD). With a …

Dysregulation of life and death at the cellular level leads to a variety of diseases. In the
nervous system, aberrant neuronal death is an outstanding feature of neurodegenerative …

… (F) The probe test performed after the experiments shown in panel E demonstrated a
beneficial effect by Aβ 42 against the reduction of reference memory caused by APP-siRNA in the …

… Significance values of gene changes in human samples are given in table (e). Outlier values
(between 1.5 and 3 times the interquartile range) and extreme values (>3 times the range) …

… 1E). We then assessed the impact of CSF1R blockade by JNJ-527 on microglial
proliferation… Based on these data, we generated a sigmoid E max pharmacokinetic/pharmacodynamics …

… , when compared to VLW or non-transgenic littermate controls (E). APP sw -tau vlw and APP
sw … 1E), and spent lower percent of time in the correct quadrant of the pool during the probe …

… Demographic covariates age, gender, and apolipoprotein E (APOE) genotype were controlled
for and included in models as potential predictors. For each comparison, the data set was …

… E, densitometric quantification of blots depicted in C and D. Data are mean ± SEM (AT-NRF2-WT
= 5 males; AT-NRF2-KO = 4 males and 1 female). Statistical analysis was performed …

… E , PD mutations fail to enhance the association of LRRK2 with RIP1. 293T cells were …
1 D,E). These findings led us to determine whether these proteins interact in brain tissue, …