(Macro)autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

… In (f–i) we analysed 20 cells per group in three independent experiments. Values are means
± sem of three independent experiments carried out in triplicate. * P<0.05, ** P<0.01, *** P<…

Autophagy is a major clearance route for intracellular aggregate-prone proteins causing
diseases such as Huntington's disease. Autophagy induction with the mTOR inhibitor rapamycin …

Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in
different proteins, such as huntingtin in Huntington’s disease and ataxin 3 in spinocerebellar …

Autophagy is an evolutionarily conserved process across eukaryotes that degrades cargoes
like aggregate-prone proteins, pathogens, damaged organelles and macromolecules via …

Genome-wide association studies have identified several loci associated with Alzheimer’s
disease (AD), including proteins involved in endocytic trafficking such as PICALM/CALM (…

BACKGROUND AND PURPOSE: Although mild or moderate traumatic brain injury (TBI) is
known to cause persistent neurologic sequelae, the underlying structural changes remain …

In an attempt to decrease the infectious complications of acute pancreatitis and its high
mortality, many investigators have conducted randomized prospective trials on the efficacy of …

The lysosomal degradation pathway of macroautophagy (herein referred to as autophagy)
plays a crucial role in cellular physiology by regulating the removal of unwanted cargoes such …

The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of
cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to …