Neurosteroids in depression: a review
F van Broekhoven, RJ Verkes - Psychopharmacology, 2003 - Springer
Rationale. A deregulation in concentrations of the neurosteroids (allo)pregnanolone and 3α,5α-tetrahydrodeoxycorticosterone
(3α,5α-TH DOC) has been found in depressed patients. …
(3α,5α-TH DOC) has been found in depressed patients. …
How progesterone impairs memory for biologically salient stimuli in healthy young women
G Van Wingen, F Van Broekhoven… - Journal of …, 2007 - Soc Neuroscience
Progesterone, or rather its neuroactive metabolite allopregnanolone, modulates amygdala
activity and thereby influences anxiety. Cognition and, in particular, memory are also altered …
activity and thereby influences anxiety. Cognition and, in particular, memory are also altered …
Effects of PhD examination stress on allopregnanolone and cortisol plasma levels and peripheral benzodiazepine receptor density
HAD Fortuyn, F Van Broekhoven, PN Span… - …, 2004 - Elsevier
Peripheral benzodiazepine receptor (PBR) density in blood platelets and plasma allopregnanolone
concentration in humans were determined following acute stress as represented by …
concentration in humans were determined following acute stress as represented by …
Progesterone selectively increases amygdala reactivity in women
GA Van Wingen, F Van Broekhoven, RJ Verkes… - Molecular …, 2008 - nature.com
The acute neural effects of progesterone are mediated by its neuroactive metabolites
allopregnanolone and pregnanolone. These neurosteroids potentiate the inhibitory actions of γ-…
allopregnanolone and pregnanolone. These neurosteroids potentiate the inhibitory actions of γ-…
Allopregnanolone and mood disorders
…, I Savic, J Strömberg, E Timby, F Van Broekhoven… - Progress in …, 2014 - Elsevier
Certain women experience negative mood symptoms during the menstrual cycle and
progesterone addition in estrogen treatments. In women with PMDD increased negative mood …
progesterone addition in estrogen treatments. In women with PMDD increased negative mood …
Oral progesterone decreases saccadic eye velocity and increases sedation in women
F Van Broekhoven, T Bäckström, RJ Verkes - Psychoneuroendocrinology, 2006 - Elsevier
The aim of this study was to investigate the neurophysiological and behavioural effects of a
single dose of progesterone in women. Allopregnanolone is a metabolite of progesterone …
single dose of progesterone in women. Allopregnanolone is a metabolite of progesterone …
Human chorionic gonadotropin treatment of anti-Hu-associated paraneoplastic neurologicalsyndromes
F Van Broekhoven, MT De Graaf… - Journal of Neurology …, 2010 - jnnp.bmj.com
Objective Paraneoplastic neurological syndromes associated with anti-Hu antibodies (Hu-PNS)
are mediated by a T-cell immune response that is directed against the Hu antigens. In …
are mediated by a T-cell immune response that is directed against the Hu antigens. In …
Effects of allopregnanolone on sedation in men, and in women on oral contraceptives
F Van Broekhoven, T Bäckström… - …, 2007 - Elsevier
Allopregnanolone is a known GABA(A) receptor agonist not previously given to men, or to
women using oral contraceptives (OC). The effects of metabolites of sex hormones on the …
women using oral contraceptives (OC). The effects of metabolites of sex hormones on the …
Dependence potential of antidepressants compared to benzodiazepines
F van Broekhoven, CC Kan, FG Zitman - Progress in Neuro …, 2002 - Elsevier
The aim of the present study was to compare the possible dependence potential of
antidepressants (ADs) to benzodiazepines (BZDs). The Schedules for Clinical Assessment in …
antidepressants (ADs) to benzodiazepines (BZDs). The Schedules for Clinical Assessment in …
Psychiatric symptoms during isotretinoin therapy
F Van Broekhoven, RJ Verkes… - Nederlands Tijdschrift …, 2003 - europepmc.org
A 22-year-old man with a known bipolar disorder was admitted to a psychiatric department
for depression and suicidal ideation. He was being given isotretinoin to treat acne conglobata…
for depression and suicidal ideation. He was being given isotretinoin to treat acne conglobata…