During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

In 2018, the US National Institute on Aging and the Alzheimer's Association proposed a
purely biological definition of Alzheimer's disease that relies on biomarkers. Although the …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

A molecular test for Alzheimer's disease could lead to better treatment and therapies. We
found 18 signaling proteins in blood plasma that can be used to classify blinded samples from …

Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, …

Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive
aging. Using the tau PET agent 18 F-AV-1451, we examined retention patterns in cognitively …

Resting-state or intrinsic connectivity network functional magnetic resonance imaging provides
a new tool for mapping large-scale neural network function and dysfunction. Recently, we …

… Rabinovici, Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s
disease, Brain, Volume 139, Issue 5, May 2016, Pages 1551–1567, https://doi.org/10.1093/…

Although β-amyloid (Aβ) plaques are a primary diagnostic criterion for Alzheimer's disease,
this pathology is commonly observed in the brains of non-demented older individuals. To …

Importance Epileptic activity associated with Alzheimer disease (AD) deserves increased
attention because it has a harmful impact on these patients, can easily go unrecognized and …