OBJECTIVE: Sacral chordomas are relatively rare, locally invasive, malignant neoplasms.
Despite surgical resection, adjuvant radiation therapy, and chemotherapy, recurrence is …

The RET proto-oncogene encodes a cell membrane tyrosine-kinase receptor protein whose
ligands belong to the glial cell line–derived neurotrophic factor. RET functions as a …

Object. Primary meningiomas arising outside the intracranial compartment (primary extradural
meningiomas [PEMs]) are rare tumors. To develop a better understanding of these tumors …

Gliomas are the most common primary malignant brain tumours and are classified into four
clinical grades 1, with the most aggressive tumours being grade 4 astrocytomas (also known …

We present evidence that some low-grade oligodendrogliomas may be comprised of proliferating
glial progenitor cells that are blocked in their ability to differentiate, whereas malignant …

cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor
Taxonomy) was established to evaluate and make practical recommendations on recent …

PURPOSE: To describe both the common and less frequently encountered magnetic
resonance (MR) imaging features of radiation therapy– and chemotherapy-induced brain injury, …

Major discoveries in the biology of nervous system tumors have raised the question of how
non‐histological data such as molecular information can be incorporated into the next W orld …

Purpose DNX-2401 (Delta-24-RGD; tasadenoturev) is a tumor-selective, replication-competent
oncolytic adenovirus. Preclinical studies demonstrated antiglioma efficacy, but the effects …

Background Therapeutic targeting of the immune checkpoints cytotoxic T-lymphocyte-associated
molecule-4 (CTLA-4) and PD-1/PD-L1 has demonstrated tumor regression in clinical …