User profiles for H. J. Wiedner
Hannah WiednerUniversity of North Carolina Chapel Hill Verified email at email.unc.edu Cited by 294 |
It's not just a phase: function and characteristics of RNA-binding proteins in phase separation
HJ Wiedner, J Giudice - Nature structural & molecular biology, 2021 - nature.com
Biomolecular condensates that form via phase separation are increasingly regarded as
coordinators of cellular reactions that regulate a wide variety of biological phenomena. Mounting …
coordinators of cellular reactions that regulate a wide variety of biological phenomena. Mounting …
Enhancement of BDNF expression and memory by HDAC inhibition requires BET bromodomain reader proteins
Histone deacetylase (HDAC) inhibitors may have therapeutic utility in multiple neurological
and psychiatric disorders, but the underlying mechanisms remain unclear. Here, we identify …
and psychiatric disorders, but the underlying mechanisms remain unclear. Here, we identify …
A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial–mesenchymal transition in cancer
Epithelial–mesenchymal transition (EMT) is an important biological process that has been
implicated in cancer metastasis. Epithelial cell adhesion molecule (EpCAM) is expressed at …
implicated in cancer metastasis. Epithelial cell adhesion molecule (EpCAM) is expressed at …
RNA processing in skeletal muscle biology and disease
RNA processing encompasses the capping, cleavage, polyadenylation and alternative splicing
of pre-mRNA. Proper muscle development relies on precise RNA processing, driven by …
of pre-mRNA. Proper muscle development relies on precise RNA processing, driven by …
JQ1 attenuates psychostimulant-but not opioid-induced conditioned place preference
Epigenetic mechanisms play important roles in the neurobiology of substance use disorder.
In particular, bromodomain and extra-terminal domain (BET) proteins, a class of histone …
In particular, bromodomain and extra-terminal domain (BET) proteins, a class of histone …
Alternative splicing regulation of membrane trafficking genes during myogenesis
ER Hinkle, HJ Wiedner, EV Torres, M Jackson… - RNA, 2022 - rnajournal.cshlp.org
Alternative splicing transitions occur during organ development, and, in numerous diseases,
splicing programs revert to fetal isoform expression. We previously found that extensive …
splicing programs revert to fetal isoform expression. We previously found that extensive …
SET domain containing 2 (SETD2) influences metabolism and alternative splicing during myogenesis
HJ Wiedner, EV Torres, RE Blue, YH Tsai… - The FEBS …, 2022 - Wiley Online Library
Epigenetic regulatory mechanisms are increasingly recognized as crucial determinants of
cellular specification and differentiation. During muscle cell differentiation (myogenesis), …
cellular specification and differentiation. During muscle cell differentiation (myogenesis), …
[PDF][PDF] RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis
HJ Wiedner, RE Blue, M Sadovsky, CA Mills… - Iscience, 2023 - cell.com
Alternative splicing is a prevalent gene-regulatory mechanism, with over 95% of multi-exon
human genes estimated to be alternatively spliced. Here, we describe a tissue-specific, …
human genes estimated to be alternatively spliced. Here, we describe a tissue-specific, …
Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice
Growing evidence indicates that targeting nociceptin receptor (NOP) signaling may have
therapeutic efficacy in treating alcohol and opioid addiction. However, little is known about the …
therapeutic efficacy in treating alcohol and opioid addiction. However, little is known about the …
Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology
RE Blue, A Koushik, NM Engels, HJ Wiedner… - The international journal …, 2018 - Elsevier
Alternative splicing is a regulatory mechanism by which multiple mRNA isoforms are
generated from single genes. Numerous genes that encode membrane trafficking proteins are …
generated from single genes. Numerous genes that encode membrane trafficking proteins are …