User profiles for H. N. Nuthall
Hugh NuthallEli Lilly Verified email at lilly.com Cited by 1097 |
[PDF][PDF] The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration
…, JM Dundee, K Pampuščenko, V Borutaite, HN Nuthall… - Cell Reports, 2021 - cell.com
Microglia are implicated in neurodegeneration, potentially by phagocytosing neurons, but it
is unclear how to block the detrimental effects of microglia while preserving their beneficial …
is unclear how to block the detrimental effects of microglia while preserving their beneficial …
Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system
FM Theriault, HN Nuthall, Z Dong, R Lo… - Journal of …, 2005 - Soc Neuroscience
Neurogenesis requires factors that regulate the decision of dividing progenitors to leave the
cell cycle and activate the neuronal differentiation program. It is shown here that the murine …
cell cycle and activate the neuronal differentiation program. It is shown here that the murine …
[HTML][HTML] A Regulatory Element in Intron 1 of the Cystic Fibrosis Transmembrane Conductance Regulator Gene (∗)
…, ML Barth, TL McDowell, DS Moulin, HN Nuthall… - Journal of Biological …, 1996 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) gene exhibits a tightly
regulated pattern of expression in human epithelial cells. The mechanism of this regulation is …
regulated pattern of expression in human epithelial cells. The mechanism of this regulation is …
Phosphorylation of serine 239 of Groucho/TLE1 by protein kinase CK2 is important for inhibition of neuronal differentiation
HN Nuthall, K Joachim, S Stifani - Molecular and cellular biology, 2004 - Taylor & Francis
Transcriptional corepressors of the Groucho (Gro)/TLE family play important roles during a
variety of developmental pathways, including neuronal differentiation. In particular, they act as …
variety of developmental pathways, including neuronal differentiation. In particular, they act as …
Evaluation of a PET radioligand to image O-GlcNAcase in brain and periphery of rhesus monkey and knock-out mouse
…, L Slieker, S Shcherbinin, HN Nuthall… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Accumulation of hyperphosphorylated tau, a microtubule-associated protein, plays an important
role in the progression of Alzheimer disease. Animal studies suggest that one strategy …
role in the progression of Alzheimer disease. Animal studies suggest that one strategy …
Multiple potential intragenic regulatory elements in the CFTR gene
The CFTR gene exhibits a complex pattern of expression that shows temporal and spatial
regulation though the control mechanisms have not been fully elucidated. We have mapped …
regulation though the control mechanisms have not been fully elucidated. We have mapped …
PET ligands [18F]LSN3316612 and [11C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain
…, E Jambrina, AJ Mannes, HN Nuthall… - Science translational …, 2020 - science.org
We aimed to develop effective radioligands for quantifying brain O-linked-β-N-acetyl-glucosamine
(O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as …
(O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as …
Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression
HN Nuthall, J Husain, KW McLarren… - Molecular and cellular …, 2002 - Taylor & Francis
Transcriptional corepressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family
regulate a number of developmental pathways in both invertebrates and vertebrates. They …
regulate a number of developmental pathways in both invertebrates and vertebrates. They …
[HTML][HTML] PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers
…, JC Ruble, N Kant, EC Collins, HN Nuthall… - EJNMMI research, 2020 - Springer
… Nuthall … Nuthall … Nuthall were employees of Eli Lilly and Co. at the time the study
was conducted. All other authors declare that they have no competing interests. …
was conducted. All other authors declare that they have no competing interests. …
Analysis of DNase-I-hypersensitive sites at the 3′ end of the cystic fibrosis transmembrane conductance regulator gene (CFTR)
HN Nuthall, DS Moulin, C Huxley… - Biochemical Journal, 1999 - portlandpress.com
The cystic fibrosis transmembrane conductance regulator gene (CFTR) exhibits a complex
pattern of expression that shows temporal and spatial regulation, although the control …
pattern of expression that shows temporal and spatial regulation, although the control …