User profiles for H. N. Nuthall

Hugh Nuthall

Eli Lilly
Verified email at lilly.com
Cited by 1097

[PDF][PDF] The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration

…, JM Dundee, K Pampuščenko, V Borutaite, HN Nuthall… - Cell Reports, 2021 - cell.com
Microglia are implicated in neurodegeneration, potentially by phagocytosing neurons, but it
is unclear how to block the detrimental effects of microglia while preserving their beneficial …

Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system

FM Theriault, HN Nuthall, Z Dong, R Lo… - Journal of …, 2005 - Soc Neuroscience
Neurogenesis requires factors that regulate the decision of dividing progenitors to leave the
cell cycle and activate the neuronal differentiation program. It is shown here that the murine …

[HTML][HTML] A Regulatory Element in Intron 1 of the Cystic Fibrosis Transmembrane Conductance Regulator Gene (∗)

…, ML Barth, TL McDowell, DS Moulin, HN Nuthall… - Journal of Biological …, 1996 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) gene exhibits a tightly
regulated pattern of expression in human epithelial cells. The mechanism of this regulation is …

Phosphorylation of serine 239 of Groucho/TLE1 by protein kinase CK2 is important for inhibition of neuronal differentiation

HN Nuthall, K Joachim, S Stifani - Molecular and cellular biology, 2004 - Taylor & Francis
Transcriptional corepressors of the Groucho (Gro)/TLE family play important roles during a
variety of developmental pathways, including neuronal differentiation. In particular, they act as …

Evaluation of a PET radioligand to image O-GlcNAcase in brain and periphery of rhesus monkey and knock-out mouse

…, L Slieker, S Shcherbinin, HN Nuthall… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Accumulation of hyperphosphorylated tau, a microtubule-associated protein, plays an important
role in the progression of Alzheimer disease. Animal studies suggest that one strategy …

Multiple potential intragenic regulatory elements in the CFTR gene

DJ Smith, HN Nuthall, ME Majetti, A Harris - Genomics, 2000 - Elsevier
The CFTR gene exhibits a complex pattern of expression that shows temporal and spatial
regulation though the control mechanisms have not been fully elucidated. We have mapped …

PET ligands [18F]LSN3316612 and [11C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain

…, E Jambrina, AJ Mannes, HN Nuthall… - Science translational …, 2020 - science.org
We aimed to develop effective radioligands for quantifying brain O-linked-β-N-acetyl-glucosamine
(O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as …

Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression

HN Nuthall, J Husain, KW McLarren… - Molecular and cellular …, 2002 - Taylor & Francis
Transcriptional corepressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family
regulate a number of developmental pathways in both invertebrates and vertebrates. They …

[HTML][HTML] PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers

…, JC Ruble, N Kant, EC Collins, HN Nuthall… - EJNMMI research, 2020 - Springer
NuthallNuthallNuthall were employees of Eli Lilly and Co. at the time the study
was conducted. All other authors declare that they have no competing interests. …

Analysis of DNase-I-hypersensitive sites at the 3′ end of the cystic fibrosis transmembrane conductance regulator gene (CFTR)

HN Nuthall, DS Moulin, C Huxley… - Biochemical Journal, 1999 - portlandpress.com
The cystic fibrosis transmembrane conductance regulator gene (CFTR) exhibits a complex
pattern of expression that shows temporal and spatial regulation, although the control …