User profiles for H. W. Gabel
Harrison W. GabelAssociate Professor, Dept of Neuroscience, Washington University School of Medicine Verified email at wustl.edu Cited by 6246 |
Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2
DNA methylation at CpG dinucleotides is an important epigenetic regulator common to
virtually all mammalian cell types, but recent evidence indicates that during early postnatal …
virtually all mammalian cell types, but recent evidence indicates that during early postnatal …
A Map of the Interactome Network of the Metazoan C. elegans
…, J Reboul, T Hirozane-Kishikawa, Q Li, HW Gabel… - Science, 2004 - science.org
To initiate studies on how protein-protein interaction (or “interactome”) networks relate to
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …
Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder
with features of autism 1 . MECP2 encodes a methyl-DNA-binding protein 2 that has been …
with features of autism 1 . MECP2 encodes a methyl-DNA-binding protein 2 that has been …
[PDF][PDF] Npas4 regulates excitatory-inhibitory balance within neural circuits through cell-type-specific gene programs
The nervous system adapts to experience by inducing a transcriptional program that controls
important aspects of synaptic plasticity. Although the molecular mechanisms of experience-…
important aspects of synaptic plasticity. Although the molecular mechanisms of experience-…
Functional Genomic Analysis of RNA Interference in C. elegans
RNA interference (RNAi) of target genes is triggered by double-stranded RNAs (dsRNAs)
processed by conserved nucleases and accessory factors. To identify the genetic components …
processed by conserved nucleases and accessory factors. To identify the genetic components …
[PDF][PDF] Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise
from defects in experience-dependent synapse maturation. RTT is caused by mutations in …
from defects in experience-dependent synapse maturation. RTT is caused by mutations in …
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
Caenorhabditis elegans homologues of the retinoblastoma (Rb) tumour suppressor complex
specify cell lineage during development 1 , 2 . Here we show that mutations in Rb pathway …
specify cell lineage during development 1 , 2 . Here we show that mutations in Rb pathway …
Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of
autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-…
autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-…
[PDF][PDF] Early-life gene expression in neurons modulates lasting epigenetic states
In mammals, the environment plays a critical role in promoting the final steps in neuronal
development during the early postnatal period. While epigenetic factors are thought to …
development during the early postnatal period. While epigenetic factors are thought to …
MicroRNA‐183 family conservation and ciliated neurosensory organ expression
…, MD Weston, B Fritzsch, HW Gabel… - Evolution & …, 2008 - Wiley Online Library
MicroRNAs (miRNAs) are an integral component of the metazoan genome and affect
posttranscriptional repression of target messenger RNAs. The extreme phylogenetic conservation …
posttranscriptional repression of target messenger RNAs. The extreme phylogenetic conservation …