DNA methylation at CpG dinucleotides is an important epigenetic regulator common to
virtually all mammalian cell types, but recent evidence indicates that during early postnatal …

To initiate studies on how protein-protein interaction (or “interactome”) networks relate to
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …

Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder
with features of autism 1 . MECP2 encodes a methyl-DNA-binding protein 2 that has been …

The nervous system adapts to experience by inducing a transcriptional program that controls
important aspects of synaptic plasticity. Although the molecular mechanisms of experience-…

RNA interference (RNAi) of target genes is triggered by double-stranded RNAs (dsRNAs)
processed by conserved nucleases and accessory factors. To identify the genetic components …

Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise
from defects in experience-dependent synapse maturation. RTT is caused by mutations in …

Caenorhabditis elegans homologues of the retinoblastoma (Rb) tumour suppressor complex
specify cell lineage during development 1 , 2 . Here we show that mutations in Rb pathway …

Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of
autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-…

In mammals, the environment plays a critical role in promoting the final steps in neuronal
development during the early postnatal period. While epigenetic factors are thought to …

MicroRNAs (miRNAs) are an integral component of the metazoan genome and affect
posttranscriptional repression of target messenger RNAs. The extreme phylogenetic conservation …