A molecular census of arcuate hypothalamus and median eminence cell types
The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown. To …
fertility and growth through molecularly distinct cell types, many of which remain unknown. To …
Integrative neurocircuits that control metabolism and food intake
JC Brüning, H Fenselau - Science, 2023 - science.org
… In a Review, Brüning and Fenselau discuss our developing understanding of the neural
pathways that underpin food intake, energy expenditure, and systemic metabolism and discuss …
pathways that underpin food intake, energy expenditure, and systemic metabolism and discuss …
[HTML][HTML] HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus
…, W Chen, AJ De Solis, H Fenselau… - Nature …, 2022 - nature.com
The hypothalamus plays a key role in coordinating fundamental body functions. Despite
recent progress in single-cell technologies, a unified catalog and molecular characterization of …
recent progress in single-cell technologies, a unified catalog and molecular characterization of …
Homeostatic circuits selectively gate food cue responses in insular cortex
…, KM Levandowski, JC Madara, H Fenselau… - Nature, 2017 - nature.com
… h, Average food cue responses from all neurons across states (n = 384 neurons, four
mice). Mean ± sem i, Time courses for food-cue-responsive neurons. j, Fraction of food-cue-…
mice). Mean ± sem i, Time courses for food-cue-responsive neurons. j, Fraction of food-cue-…
A rapidly acting glutamatergic ARC→ PVH satiety circuit postsynaptically regulated by α-MSH
H Fenselau, JN Campbell, AMJ Verstegen… - Nature …, 2017 - nature.com
… no longer affects feeding over a 2-h period 18 . However, in these same mice, AgRP, working
through MC4Rs, induces feeding, but only after 4 h of stimulation 18 . Thus, the ability of …
through MC4Rs, induces feeding, but only after 4 h of stimulation 18 . Thus, the ability of …
[PDF][PDF] Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism
…, FT Wunderlich, JC Brüning, H Fenselau - Cell metabolism, 2021 - cell.com
… , which avoid vagal afferents but target spinal afferents (Figure S1H), were not observed
in the stomach and duodenum (Figures S2H and S2I). Thus, taken together with the above …
in the stomach and duodenum (Figures S2H and S2I). Thus, taken together with the above …
[HTML][HTML] Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting
…, F Reimann, FM Gribble, H Fenselau… - Nature …, 2021 - nature.com
… 1 h, incubated in 50% methanol (in PBS) for 1 h, 80% methanol for 1 h and two times in 100%
methanol for 1 h… bleached with 5% H 2 O 2 in 20% DMSO/methanol (one vol 30% H 2 O 2 /…
methanol for 1 h… bleached with 5% H 2 O 2 in 20% DMSO/methanol (one vol 30% H 2 O 2 /…
A hypothalamic circuit for the circadian control of aggression
WD Todd, H Fenselau, JL Wang, R Zhang… - Nature …, 2018 - nature.com
… Because IVM has a long half-life and minor off-target effects (drowsiness) that are no longer
present after 24 h 48 , we tested these mice using the resident–intruder assay described …
present after 24 h 48 , we tested these mice using the resident–intruder assay described …
[PDF][PDF] PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding
…, BB Lowell, HU Zeilhofer, H Backes, H Fenselau… - Neuron, 2020 - cell.com
Calorie-rich diets induce hyperphagia and promote obesity, although the underlying
mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice …
mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice …
[PDF][PDF] Food perception primes hepatic ER homeostasis via melanocortin-dependent control of mTOR activation
…, S Günther, T Langer, K Rahmouni, H Fenselau… - Cell, 2018 - cell.com
Adaptation of liver to the postprandial state requires coordinated regulation of protein synthesis
and folding aligned with changes in lipid metabolism. Here we demonstrate that sensory …
and folding aligned with changes in lipid metabolism. Here we demonstrate that sensory …