Alongside playing structural roles, the extracellular matrix (ECM) acts as an interaction
platform for cellular homeostasis, organ development, and maintenance. The necessity of the …

Both transmembrane and extracellular cues, one of which is collagen XIII, regulate the
formation and function of the neuromuscular synapse, and their absence results in myasthenia. …

Collagen XIII occurs as both a transmembrane-bound and a shed extracellular protein and is
able to regulate the formation and function of neuromuscular synapses. Its absence results …

Mutations in the COL13A1 gene result in congenital myasthenic syndrome type 19 (CMS19),
a disease of neuromuscular synapses and including various skeletal manifestations, …

Osteoporosis is the most common degenerative bone disease that occurs when the balance
of bone production and resorption is perturbed. Loss of bone mass or alteration in its quality …

Correct expression and localization of collagen XIII are crucial for the normal formation and
function of the neuromuscular system - Härönen - 2019 - European Journal of Neuroscience …

… For this purpose, cells were synchronized in Go by serum deprivation for 48 h and then
stimulated with 20% FCS for 4 h. The results in Figure 7(b) show that the expression profile was …

Neuromuscular development is a multistep process that involves interactions among various
extracellular and transmembrane molecules that facilitate the precise targeting of motor …

… A, Härönen H, Keski-Filppula R, unpublished). Thus collagen XIII contributes to the
differentiation of certain cell types, such as osteoblasts, maturation of the NMJ and the structural …

Next generation sequencing techniques were recently used to show mutations in COL13A1
cause synaptic basal lamina-associated congenital myasthenic syndrome type 19. Animal …