… (126) that conantokin-G enhanced strychnine-insensitive [ 3 H]-glycine binding to rat forebrain
membranes in a concentration-dependent manner (ED 50 152 nM). Neither competitive …

THE sodium channel, one of the family of structurally homologous voltage-gated ion channels
1 , differs from other members, such as the calcium and the potassium channels, in its high …

The SS2 and adjacent regions of the 4 internal repeats of sodium channel II were subjected
to single mutations involving, mainly, charged amino acid residues. These sodium channel …

Cone snails are marine predators that use venoms to immobilize their prey. The venoms of
these mollusks contain a cocktail of peptides that mainly target different voltage- and ligand-…

Voltage-gated ion channels are key molecules for the generation of electrical signals in cells.
They are integral membrane proteins which are activated by a depolarized membrane …

… Heinrich Terlau", Ki-Joon Shonij, Michelle Grilley, Martin Stocker*, Walter Stühmer* & …
Digestion then proceeds and, in - 1–2 h, the Snail regurgitates the scales and bones of the fish …

We have cloned a mammalian (rat) homologue of Drosophila ether á go‐go (eag) cDNA,
which encodes a distinct type of voltage activated potassium (K) channel. The derived …

Extracellular potassium concentration is actively maintained within narrow limits in all higher
organisms. Slight variations in extracellular potassium levels can induce major alterations …

We report the characterization of a new sodium channel blocker, μ-conotoxin PIIIA (μ-PIIIA).
The peptide has been synthesized chemically and its disulfide bridging pattern determined. …

… Oxidative folding was carried out for 2 h in buffered solution (0.1 m Tris-HCl, pH 7.5) containing
1 mm EDTA, 1 mm reduced and 1 mm oxidized glutathione. The refolded peptides were …